The molecular mechanism and cellular functions of mitochondrial division

Laura L. Lackner, Jodi M. Nunnari

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Mitochondria are highly dynamic organelles that continuously divide and fuse. These dynamic processes regulate the size, shape, and distribution of the mitochondrial network. In addition, mitochondrial division and fusion play critical roles in cell physiology. This review will focus on the dynamic process of mitochondrial division, which is highly conserved from yeast to humans. We will discuss what is known about how the essential components of the division machinery function to mediate mitochondrial division and then focus on proteins that have been implicated in division but whose functions remain unclear. We will then briefly discuss the cellular functions of mitochondrial division and the problems that arise when division is disrupted.

Original languageEnglish (US)
Pages (from-to)1138-1144
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1792
Issue number12
DOIs
StatePublished - Dec 2009

Keywords

  • Dnm1
  • Drp1
  • Dynamin-related protein
  • Fis1
  • Mitochondrial dynamics

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

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