TY - JOUR
T1 - The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish
AU - Huising, Mark O.
AU - Stet, René J.M.
AU - Savelkoul, Huub F.J.
AU - Verburg-Van Kemenade, B. M.Lidy
PY - 2004/5/3
Y1 - 2004/5/3
N2 - The cytokine network is an important homeostatic system with potent activities in immune surveillance, growth, developmental and repair processes. Although interleukin-1β (IL-1β) is considered a pivotal pro-inflammatory cytokine, merely focussing on its inflammatory role would be too narrow an approach. Elucidation of the human, the mouse and the Fugu rubripes (pufferfish) genome now enables a more comprehensive overview of this cytokine family and its receptors in several vertebrate classes. Phylogenetic analyses of the IL-1 family members, comprising over 80 sequences of various fish, amphibian, avian and mammalian species, reveal that for only a few mammalian IL-1 family members unambiguous orthologues have been found in fish, indicating a recent origin of some of the mammalian IL-1 family members. Interestingly, the Fugu genome did reveal teleost orthologues for IL-18 and its putative receptor complex. All teleost IL-1β sequences cluster separately from IL-1β sequences of other species. In contrast, a number of IL-1 receptor family members have well conserved fish orthologues. This supports the concept of an ancestral role of this family, possibly in the brain.
AB - The cytokine network is an important homeostatic system with potent activities in immune surveillance, growth, developmental and repair processes. Although interleukin-1β (IL-1β) is considered a pivotal pro-inflammatory cytokine, merely focussing on its inflammatory role would be too narrow an approach. Elucidation of the human, the mouse and the Fugu rubripes (pufferfish) genome now enables a more comprehensive overview of this cytokine family and its receptors in several vertebrate classes. Phylogenetic analyses of the IL-1 family members, comprising over 80 sequences of various fish, amphibian, avian and mammalian species, reveal that for only a few mammalian IL-1 family members unambiguous orthologues have been found in fish, indicating a recent origin of some of the mammalian IL-1 family members. Interestingly, the Fugu genome did reveal teleost orthologues for IL-18 and its putative receptor complex. All teleost IL-1β sequences cluster separately from IL-1β sequences of other species. In contrast, a number of IL-1 receptor family members have well conserved fish orthologues. This supports the concept of an ancestral role of this family, possibly in the brain.
KW - Evolution
KW - Fish
KW - IL-1
KW - IL-18
KW - Immune system
KW - Interleukin-1 family
KW - Neuroendocrine-immune interaction
UR - http://www.scopus.com/inward/record.url?scp=0842324557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0842324557&partnerID=8YFLogxK
U2 - 10.1016/j.dci.2003.09.005
DO - 10.1016/j.dci.2003.09.005
M3 - Article
C2 - 15062640
AN - SCOPUS:0842324557
VL - 28
SP - 395
EP - 413
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
SN - 0145-305X
IS - 5
ER -