The molecular basis of primary biliary cirrhosis: Interfacing clinical medicine and wet bench research

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3 Scopus citations

Abstract

Primary biliary cirrhosis (PBC) is an automatic destructive disease of the intrahepatic bile ducts, including inflammation of the portal triads of the liver followed by fibrosis and eventually liver failure. The most characteristic feature of PBC is an elevation level of serum alkaline phosphatase and the presence of animitochondrial antibodies (AMA). This paper discusses the molecular basis of PBC which is the subject of the interfacing of clinical medicine and wet bench research.

Original languageEnglish (US)
Pages (from-to)22-30
Number of pages9
JournalIsrael Journal of Medical Sciences
Volume31
Issue number1
StatePublished - Jan 1995

Keywords

  • Antimitochondrial antibodies
  • Autoimmunity
  • Liver immunology
  • Primary biliary cirrhosis T cells

ASJC Scopus subject areas

  • Bioengineering
  • Medicine(all)

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