The molecular basis of immune regulation in autoimmunity

Shu Han Yang, Cai yue Gao, Liang Li, Christopher Chang, Patrick S Leung, M. Eric Gershwin, Zhe Xiong Lian

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Autoimmune diseases can be triggered and modulated by various molecular and cellular characteristics. Themechanisms of autoimmunity and the pathogenesis of autoimmune diseases have been investigated for several decades. It is well accepted that autoimmunity is caused by dysregulated/dysfunctional immune susceptible genes and environmental factors. There are multiple physiological mechanisms that regulate and control self-reactivity, but which can also lead to tolerance breakdown when in defect. The majority of autoreactive T or B cells are eliminated during the development of central tolerance by negative selection. Regulatory cells such as Tregs (regulatory T) and MSCs (mesenchymal stem cells), and molecules such as CTLA-4 (cytotoxic T-lymphocyte associated antigen 4) and IL (interleukin) 10 (IL-10), help to eliminate autoreactive cells that escaped to the periphery in order to prevent development of autoimmunity. Knowledge of the molecular basis of immune regulation is needed to further our understanding of the underlying mechanisms of loss of tolerance in autoimmune diseases and pave the way for the development of more effective, specific, and safer therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)43-67
Number of pages25
JournalClinical Science
Volume132
Issue number1
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Medicine(all)

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