The modulation of inflammatory gene expression by lipids: Mediation through toll-like receptors

Joo Y. Lee, Daniel H. Hwang

Research output: Contribution to journalArticlepeer-review

160 Scopus citations

Abstract

Toll-like receptors (TLRs) were evolved to detect invading pathogens and to induce innate immune responses in order to mount host defense mechanisms. It becomes apparent that the activation of certain TLRs is also modulated by endogenous molecules including lipid components, fatty acids. Results from epidemiological and animal studies demonstrated that saturated and polyunsaturated dietary fatty acids can differentially modify the risk of development of many chronic diseases. Inflammation is now recognized as an important underlying etiologic condition for the pathogenesis of many chronic diseases. Therefore, if the activation of TLRs and consequent inflammatory and immune responses are differentially modulated by types of lipids in vivo, this would suggest that the risk of the development of chronic inflammatory diseases and the host defense against microbial infection may be modified by the types of dietary fat consumed.

Original languageEnglish (US)
Pages (from-to)174-185
Number of pages12
JournalMolecules and Cells
Volume21
Issue number2
StatePublished - Apr 30 2006

Keywords

  • Fatty acids
  • Inflammation
  • Lipids
  • Toll-like receptors

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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