The modifier model of autism and social development in higher functioning children

Peter Clive Mundy, Heather A. Henderson, Anne Pradella Inge, Drew C. Coman

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The study of phenotypic variability in social impairments and comorbid emotional disorders in autism is important because it provides information on phenotypic differences that currently complicate diagnosis, research, and treatment of this disorder. Currently, though, relatively little is known about the processes that contribute to individual differences in social impairments and comorbidity in autism. In this paper, we present a model that suggests modifier processes (MPs), which are not necessarily specific to the syndrome, refract or alter the expression of autism and contribute to fundamental behavioral and psychological differences in children diagnosed with this disorder. One MPs involves the somewhat surprising tendency of some children with higher functioning autism (HFA) to make attributions about other peoples thoughts, although they have social cognitive deficits. Just as in other children, the attributions of children with HFA are linked to some of their behavioral problems. Another MP involves the influence of differences in motivation associated with the behavioral activation and inhibition systems that can be assessed with measures of anterior EEG asymmetry. This dimension of motivation may be linked to how active but inappropriate and withdrawn children with HFA may appear. Third, differences in the self-monitoring of errors among children with HFA appear to be related to individual differences in IQ and social symptom severity in these children. The possible role of these MPs in diagnostic subgroups and differences in treatment responses among children with HFA are discussed. In addition, the role of MPs in understanding the effects associated with specific genetic functions in autism, such as those associated with the serotonin transporter gene (5-HTTLPR), is discussed. A conclusion of this paper is that the varied expression of autism may require that we understand how autism nteracts with other non-syndrome-specific processes that are related to individual differences in all people. copyright 2007 by TASH.

Original languageEnglish (US)
Pages (from-to)124-139
Number of pages16
JournalResearch and Practice for Persons with Severe Disabilities
Volume32
Issue number2
StatePublished - Jun 2007
Externally publishedYes

Fingerprint

Autistic Disorder
Individuality
Motivation
Serotonin Plasma Membrane Transport Proteins
Comorbidity
Electroencephalography
Psychology

Keywords

  • Autism
  • Comorbity
  • Motivation and attributional processes
  • Phenotypic variability
  • Self-monitoring

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Health Professions(all)

Cite this

The modifier model of autism and social development in higher functioning children. / Mundy, Peter Clive; Henderson, Heather A.; Inge, Anne Pradella; Coman, Drew C.

In: Research and Practice for Persons with Severe Disabilities, Vol. 32, No. 2, 06.2007, p. 124-139.

Research output: Contribution to journalArticle

Mundy, Peter Clive ; Henderson, Heather A. ; Inge, Anne Pradella ; Coman, Drew C. / The modifier model of autism and social development in higher functioning children. In: Research and Practice for Persons with Severe Disabilities. 2007 ; Vol. 32, No. 2. pp. 124-139.
@article{2ef83024cda9434d8944d8ce76584f13,
title = "The modifier model of autism and social development in higher functioning children",
abstract = "The study of phenotypic variability in social impairments and comorbid emotional disorders in autism is important because it provides information on phenotypic differences that currently complicate diagnosis, research, and treatment of this disorder. Currently, though, relatively little is known about the processes that contribute to individual differences in social impairments and comorbidity in autism. In this paper, we present a model that suggests modifier processes (MPs), which are not necessarily specific to the syndrome, refract or alter the expression of autism and contribute to fundamental behavioral and psychological differences in children diagnosed with this disorder. One MPs involves the somewhat surprising tendency of some children with higher functioning autism (HFA) to make attributions about other peoples thoughts, although they have social cognitive deficits. Just as in other children, the attributions of children with HFA are linked to some of their behavioral problems. Another MP involves the influence of differences in motivation associated with the behavioral activation and inhibition systems that can be assessed with measures of anterior EEG asymmetry. This dimension of motivation may be linked to how active but inappropriate and withdrawn children with HFA may appear. Third, differences in the self-monitoring of errors among children with HFA appear to be related to individual differences in IQ and social symptom severity in these children. The possible role of these MPs in diagnostic subgroups and differences in treatment responses among children with HFA are discussed. In addition, the role of MPs in understanding the effects associated with specific genetic functions in autism, such as those associated with the serotonin transporter gene (5-HTTLPR), is discussed. A conclusion of this paper is that the varied expression of autism may require that we understand how autism nteracts with other non-syndrome-specific processes that are related to individual differences in all people. copyright 2007 by TASH.",
keywords = "Autism, Comorbity, Motivation and attributional processes, Phenotypic variability, Self-monitoring",
author = "Mundy, {Peter Clive} and Henderson, {Heather A.} and Inge, {Anne Pradella} and Coman, {Drew C.}",
year = "2007",
month = "6",
language = "English (US)",
volume = "32",
pages = "124--139",
journal = "Research and Practice for Persons with Severe Disabilities",
issn = "1540-7969",
publisher = "Association for Persons with Severe Handicaps",
number = "2",

}

TY - JOUR

T1 - The modifier model of autism and social development in higher functioning children

AU - Mundy, Peter Clive

AU - Henderson, Heather A.

AU - Inge, Anne Pradella

AU - Coman, Drew C.

PY - 2007/6

Y1 - 2007/6

N2 - The study of phenotypic variability in social impairments and comorbid emotional disorders in autism is important because it provides information on phenotypic differences that currently complicate diagnosis, research, and treatment of this disorder. Currently, though, relatively little is known about the processes that contribute to individual differences in social impairments and comorbidity in autism. In this paper, we present a model that suggests modifier processes (MPs), which are not necessarily specific to the syndrome, refract or alter the expression of autism and contribute to fundamental behavioral and psychological differences in children diagnosed with this disorder. One MPs involves the somewhat surprising tendency of some children with higher functioning autism (HFA) to make attributions about other peoples thoughts, although they have social cognitive deficits. Just as in other children, the attributions of children with HFA are linked to some of their behavioral problems. Another MP involves the influence of differences in motivation associated with the behavioral activation and inhibition systems that can be assessed with measures of anterior EEG asymmetry. This dimension of motivation may be linked to how active but inappropriate and withdrawn children with HFA may appear. Third, differences in the self-monitoring of errors among children with HFA appear to be related to individual differences in IQ and social symptom severity in these children. The possible role of these MPs in diagnostic subgroups and differences in treatment responses among children with HFA are discussed. In addition, the role of MPs in understanding the effects associated with specific genetic functions in autism, such as those associated with the serotonin transporter gene (5-HTTLPR), is discussed. A conclusion of this paper is that the varied expression of autism may require that we understand how autism nteracts with other non-syndrome-specific processes that are related to individual differences in all people. copyright 2007 by TASH.

AB - The study of phenotypic variability in social impairments and comorbid emotional disorders in autism is important because it provides information on phenotypic differences that currently complicate diagnosis, research, and treatment of this disorder. Currently, though, relatively little is known about the processes that contribute to individual differences in social impairments and comorbidity in autism. In this paper, we present a model that suggests modifier processes (MPs), which are not necessarily specific to the syndrome, refract or alter the expression of autism and contribute to fundamental behavioral and psychological differences in children diagnosed with this disorder. One MPs involves the somewhat surprising tendency of some children with higher functioning autism (HFA) to make attributions about other peoples thoughts, although they have social cognitive deficits. Just as in other children, the attributions of children with HFA are linked to some of their behavioral problems. Another MP involves the influence of differences in motivation associated with the behavioral activation and inhibition systems that can be assessed with measures of anterior EEG asymmetry. This dimension of motivation may be linked to how active but inappropriate and withdrawn children with HFA may appear. Third, differences in the self-monitoring of errors among children with HFA appear to be related to individual differences in IQ and social symptom severity in these children. The possible role of these MPs in diagnostic subgroups and differences in treatment responses among children with HFA are discussed. In addition, the role of MPs in understanding the effects associated with specific genetic functions in autism, such as those associated with the serotonin transporter gene (5-HTTLPR), is discussed. A conclusion of this paper is that the varied expression of autism may require that we understand how autism nteracts with other non-syndrome-specific processes that are related to individual differences in all people. copyright 2007 by TASH.

KW - Autism

KW - Comorbity

KW - Motivation and attributional processes

KW - Phenotypic variability

KW - Self-monitoring

UR - http://www.scopus.com/inward/record.url?scp=34948888116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34948888116&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:34948888116

VL - 32

SP - 124

EP - 139

JO - Research and Practice for Persons with Severe Disabilities

JF - Research and Practice for Persons with Severe Disabilities

SN - 1540-7969

IS - 2

ER -