The missing link between envelope formation and fusion in alphaviruses

Henrik Garoff, R. Holland Cheng

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Recent structural analyses of the Semliki Forest virus envelope suggest that the spike subunit E1, which is responsible for virus membrane fusion, also maintains the organization of the spike protein shell that encompasses the enveloped virus. This gives E1 a unique opportunity to control membrane stability during the membrane fusion reaction. Here, we present a model for this control mechanism.

Original languageEnglish (US)
Pages (from-to)408-410
Number of pages3
JournalTrends in Microbiology
Volume9
Issue number9
DOIs
StatePublished - Sep 1 2001
Externally publishedYes

Fingerprint

Semliki forest virus
Alphavirus
Virus Internalization
Membrane Fusion
Viruses
Membranes
Proteins

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology

Cite this

The missing link between envelope formation and fusion in alphaviruses. / Garoff, Henrik; Cheng, R. Holland.

In: Trends in Microbiology, Vol. 9, No. 9, 01.09.2001, p. 408-410.

Research output: Contribution to journalArticle

Garoff, Henrik ; Cheng, R. Holland. / The missing link between envelope formation and fusion in alphaviruses. In: Trends in Microbiology. 2001 ; Vol. 9, No. 9. pp. 408-410.
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