The missing link between envelope formation and fusion in alphaviruses

Henrik Garoff, R. Holland Cheng

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Recent structural analyses of the Semliki Forest virus envelope suggest that the spike subunit E1, which is responsible for virus membrane fusion, also maintains the organization of the spike protein shell that encompasses the enveloped virus. This gives E1 a unique opportunity to control membrane stability during the membrane fusion reaction. Here, we present a model for this control mechanism.

Original languageEnglish (US)
Pages (from-to)408-410
Number of pages3
JournalTrends in Microbiology
Issue number9
StatePublished - Sep 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology


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