The Microbiota of the Extremely Preterm Infant

Mark Underwood; Kristin Sohn

doi:10.1016/j.clp.2017.01.005

The Microbiota of the Extremely Preterm Infant

Mark Underwood, Kristin Sohn

Neonatology

Research output: Contribution to journal › Article

17 Scopus citations

Abstract

Colonization of the extremely preterm infant's gastrointestinal tract and skin begins in utero and is influenced by a variety of factors, the most important likely including gestational age and environmental exposures. The composition of the intestinal and skin microbiota influences the developing innate and adaptive immune responses with short-term and long-term consequences including altered risks for developing necrotizing enterocolitis, sepsis, and a wide variety of microbe-related diseases of children and adults. Alteration of the composition of the microbiota to decrease disease risk is particularly appealing for this ultra-high-risk cohort that is brand new from an evolutionary standpoint.

Original language	English (US)
Journal	Clinics in Perinatology
DOIs	https://doi.org/10.1016/j.clp.2017.01.005
State	Accepted/In press - 2017

Fingerprint

Keywords

Dysbiosis
Intestinal tract
Late-onset sepsis
Microbiota
Necrotizing enterocolitis
Oral cavity
Skin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

Cite this

Underwood, M., & Sohn, K. (Accepted/In press). The Microbiota of the Extremely Preterm Infant. Clinics in Perinatology. https://doi.org/10.1016/j.clp.2017.01.005

@article{212f4f4137e64df69cb48b564c16444c,

title = "The Microbiota of the Extremely Preterm Infant",

abstract = "Colonization of the extremely preterm infant's gastrointestinal tract and skin begins in utero and is influenced by a variety of factors, the most important likely including gestational age and environmental exposures. The composition of the intestinal and skin microbiota influences the developing innate and adaptive immune responses with short-term and long-term consequences including altered risks for developing necrotizing enterocolitis, sepsis, and a wide variety of microbe-related diseases of children and adults. Alteration of the composition of the microbiota to decrease disease risk is particularly appealing for this ultra-high-risk cohort that is brand new from an evolutionary standpoint.",

keywords = "Dysbiosis, Intestinal tract, Late-onset sepsis, Microbiota, Necrotizing enterocolitis, Oral cavity, Skin",

author = "Mark Underwood and Kristin Sohn",

year = "2017",

doi = "10.1016/j.clp.2017.01.005",

language = "English (US)",

journal = "Clinics in Perinatology",

issn = "0095-5108",

publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - The Microbiota of the Extremely Preterm Infant

AU - Underwood, Mark

AU - Sohn, Kristin

PY - 2017

Y1 - 2017

N2 - Colonization of the extremely preterm infant's gastrointestinal tract and skin begins in utero and is influenced by a variety of factors, the most important likely including gestational age and environmental exposures. The composition of the intestinal and skin microbiota influences the developing innate and adaptive immune responses with short-term and long-term consequences including altered risks for developing necrotizing enterocolitis, sepsis, and a wide variety of microbe-related diseases of children and adults. Alteration of the composition of the microbiota to decrease disease risk is particularly appealing for this ultra-high-risk cohort that is brand new from an evolutionary standpoint.

AB - Colonization of the extremely preterm infant's gastrointestinal tract and skin begins in utero and is influenced by a variety of factors, the most important likely including gestational age and environmental exposures. The composition of the intestinal and skin microbiota influences the developing innate and adaptive immune responses with short-term and long-term consequences including altered risks for developing necrotizing enterocolitis, sepsis, and a wide variety of microbe-related diseases of children and adults. Alteration of the composition of the microbiota to decrease disease risk is particularly appealing for this ultra-high-risk cohort that is brand new from an evolutionary standpoint.

KW - Dysbiosis

KW - Intestinal tract

KW - Late-onset sepsis

KW - Microbiota

KW - Necrotizing enterocolitis

KW - Oral cavity

KW - Skin

UR - http://www.scopus.com/inward/record.url?scp=85016062184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016062184&partnerID=8YFLogxK

U2 - 10.1016/j.clp.2017.01.005

DO - 10.1016/j.clp.2017.01.005

M3 - Article

C2 - 28477669

AN - SCOPUS:85016062184

JO - Clinics in Perinatology

JF - Clinics in Perinatology

SN - 0095-5108

ER -

Access to Document

10.1016/j.clp.2017.01.005