The Microbiota of the Extremely Preterm Infant

Mark Underwood, Kristin Sohn

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Colonization of the extremely preterm infant's gastrointestinal tract and skin begins in utero and is influenced by a variety of factors, the most important likely including gestational age and environmental exposures. The composition of the intestinal and skin microbiota influences the developing innate and adaptive immune responses with short-term and long-term consequences including altered risks for developing necrotizing enterocolitis, sepsis, and a wide variety of microbe-related diseases of children and adults. Alteration of the composition of the microbiota to decrease disease risk is particularly appealing for this ultra-high-risk cohort that is brand new from an evolutionary standpoint.

Original languageEnglish (US)
JournalClinics in Perinatology
DOIs
StateAccepted/In press - 2017

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Keywords

  • Dysbiosis
  • Intestinal tract
  • Late-onset sepsis
  • Microbiota
  • Necrotizing enterocolitis
  • Oral cavity
  • Skin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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