The Microbiota of the Extremely Preterm Infant

Mark Underwood; Kristin Sohn

doi:10.1016/j.clp.2017.01.005

The Microbiota of the Extremely Preterm Infant

Mark Underwood, Kristin Sohn

Neonatology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Colonization of the extremely preterm infant's gastrointestinal tract and skin begins in utero and is influenced by a variety of factors, the most important likely including gestational age and environmental exposures. The composition of the intestinal and skin microbiota influences the developing innate and adaptive immune responses with short-term and long-term consequences including altered risks for developing necrotizing enterocolitis, sepsis, and a wide variety of microbe-related diseases of children and adults. Alteration of the composition of the microbiota to decrease disease risk is particularly appealing for this ultra-high-risk cohort that is brand new from an evolutionary standpoint.

Original language	English (US)
Journal	Clinics in Perinatology
DOIs	https://doi.org/10.1016/j.clp.2017.01.005
State	Accepted/In press - 2017

Keywords

Dysbiosis
Intestinal tract
Late-onset sepsis
Microbiota
Necrotizing enterocolitis
Oral cavity
Skin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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title = "The Microbiota of the Extremely Preterm Infant",

abstract = "Colonization of the extremely preterm infant's gastrointestinal tract and skin begins in utero and is influenced by a variety of factors, the most important likely including gestational age and environmental exposures. The composition of the intestinal and skin microbiota influences the developing innate and adaptive immune responses with short-term and long-term consequences including altered risks for developing necrotizing enterocolitis, sepsis, and a wide variety of microbe-related diseases of children and adults. Alteration of the composition of the microbiota to decrease disease risk is particularly appealing for this ultra-high-risk cohort that is brand new from an evolutionary standpoint.",

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AB - Colonization of the extremely preterm infant's gastrointestinal tract and skin begins in utero and is influenced by a variety of factors, the most important likely including gestational age and environmental exposures. The composition of the intestinal and skin microbiota influences the developing innate and adaptive immune responses with short-term and long-term consequences including altered risks for developing necrotizing enterocolitis, sepsis, and a wide variety of microbe-related diseases of children and adults. Alteration of the composition of the microbiota to decrease disease risk is particularly appealing for this ultra-high-risk cohort that is brand new from an evolutionary standpoint.

KW - Dysbiosis

KW - Intestinal tract

KW - Late-onset sepsis

KW - Microbiota

KW - Necrotizing enterocolitis

KW - Oral cavity

KW - Skin

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The Microbiota of the Extremely Preterm Infant

Abstract

Keywords

ASJC Scopus subject areas

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