Abstract
The trillions of microorganisms inhabiting human mucosal surfaces participate intricately in local homeostatic processes as well as development and function of the host immune system. These microorganisms, collectively referred to as the "microbiome," play a vital role in modulating the balance between clearance of pathogenic organisms and tolerance of commensal cells, including but not limited to human allografts. Advances in immunology, gnotobiotics, and culture-independent molecular techniques have provided growing insights into the complex relationship between themicrobiome and the host, how it ismodified by variables such as immunosuppressive and antimicrobial drugs, and its potential impact on posttransplantation outcomes. Here, we provide an overview of fundamental principles, recent discoveries, and clinical implications of this promising field of research.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 56-62 |
| Number of pages | 7 |
| Journal | Transplantation |
| Volume | 101 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2017 |
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ASJC Scopus subject areas
- Transplantation
Cite this
The microbiome and immune regulation after transplantation. / Tabibian, James H.; Kenderian, Saad S.
In: Transplantation, Vol. 101, No. 1, 2017, p. 56-62.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The microbiome and immune regulation after transplantation
AU - Tabibian, James H.
AU - Kenderian, Saad S.
PY - 2017
Y1 - 2017
N2 - The trillions of microorganisms inhabiting human mucosal surfaces participate intricately in local homeostatic processes as well as development and function of the host immune system. These microorganisms, collectively referred to as the "microbiome," play a vital role in modulating the balance between clearance of pathogenic organisms and tolerance of commensal cells, including but not limited to human allografts. Advances in immunology, gnotobiotics, and culture-independent molecular techniques have provided growing insights into the complex relationship between themicrobiome and the host, how it ismodified by variables such as immunosuppressive and antimicrobial drugs, and its potential impact on posttransplantation outcomes. Here, we provide an overview of fundamental principles, recent discoveries, and clinical implications of this promising field of research.
AB - The trillions of microorganisms inhabiting human mucosal surfaces participate intricately in local homeostatic processes as well as development and function of the host immune system. These microorganisms, collectively referred to as the "microbiome," play a vital role in modulating the balance between clearance of pathogenic organisms and tolerance of commensal cells, including but not limited to human allografts. Advances in immunology, gnotobiotics, and culture-independent molecular techniques have provided growing insights into the complex relationship between themicrobiome and the host, how it ismodified by variables such as immunosuppressive and antimicrobial drugs, and its potential impact on posttransplantation outcomes. Here, we provide an overview of fundamental principles, recent discoveries, and clinical implications of this promising field of research.
UR - http://www.scopus.com/inward/record.url?scp=84981738102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84981738102&partnerID=8YFLogxK
U2 - 10.1097/TP.0000000000001444
DO - 10.1097/TP.0000000000001444
M3 - Review article
C2 - 27517729
AN - SCOPUS:84981738102
VL - 101
SP - 56
EP - 62
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 1
ER -