Abstract
The relationship of Citrobacter freundii (4280) to the development of colonic hyperplasia in mice was investigted. The number of Citrobacter freundii (4280) in the descending colon were quantitated at intervals following experimental inoculation, and findings were correlated with previously reported histological and ultrastructural findings. Citrobacter freundii (4280) was a transient infection, lasting 2-3 weeks, after which time mice no longer harbored the organism. Neomycin sulfate and tetracycline hydrochloride, when administered in the drinking water, were useful in the prevention of infection as well as ablation of established infection. The presence of Citrobacter freundii (4280) for as little as 2 days was sufficient stimulus to result in detectable mucosal hyperplasia. The longer the bacterium was present, through 10 days, the greater the hyperplasia.
| Original language | English (US) |
|---|---|
| Title of host publication | Laboratory Animal Science |
| Pages | 167-173 |
| Number of pages | 7 |
| Volume | 30 |
| Edition | 2 I |
| State | Published - 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
The microbiology of transmissible murine colonic hyperplasia. / Barthold, Stephen W.
Laboratory Animal Science. Vol. 30 2 I. ed. 1980. p. 167-173.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - The microbiology of transmissible murine colonic hyperplasia
AU - Barthold, Stephen W
PY - 1980
Y1 - 1980
N2 - The relationship of Citrobacter freundii (4280) to the development of colonic hyperplasia in mice was investigted. The number of Citrobacter freundii (4280) in the descending colon were quantitated at intervals following experimental inoculation, and findings were correlated with previously reported histological and ultrastructural findings. Citrobacter freundii (4280) was a transient infection, lasting 2-3 weeks, after which time mice no longer harbored the organism. Neomycin sulfate and tetracycline hydrochloride, when administered in the drinking water, were useful in the prevention of infection as well as ablation of established infection. The presence of Citrobacter freundii (4280) for as little as 2 days was sufficient stimulus to result in detectable mucosal hyperplasia. The longer the bacterium was present, through 10 days, the greater the hyperplasia.
AB - The relationship of Citrobacter freundii (4280) to the development of colonic hyperplasia in mice was investigted. The number of Citrobacter freundii (4280) in the descending colon were quantitated at intervals following experimental inoculation, and findings were correlated with previously reported histological and ultrastructural findings. Citrobacter freundii (4280) was a transient infection, lasting 2-3 weeks, after which time mice no longer harbored the organism. Neomycin sulfate and tetracycline hydrochloride, when administered in the drinking water, were useful in the prevention of infection as well as ablation of established infection. The presence of Citrobacter freundii (4280) for as little as 2 days was sufficient stimulus to result in detectable mucosal hyperplasia. The longer the bacterium was present, through 10 days, the greater the hyperplasia.
UR - http://www.scopus.com/inward/record.url?scp=0019312238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019312238&partnerID=8YFLogxK
M3 - Chapter
C2 - 7052371
AN - SCOPUS:0019312238
VL - 30
SP - 167
EP - 173
BT - Laboratory Animal Science
ER -