Abstract
Pseudomonas aeruginosa is a model pathogen with which to advance the notion that microbial endocrinology plays a central role in the pathogenesis of bacteria and other microbes. P. aeruginosa is a gram-negative opportunistic pathogen that can infect a variety of host species, including Arabidopsis, Drosophila, Caenorhabditis elegans, rodents, and man. Like many opportunistic pathogens, virulence expression in P. aeruginosa is not an invariant phenotype. Some investigators consider P. aeruginosa to be an accidental pathogen to man given that it does not appear to have co-evolved with the human immune system; as such it has been assumed to be rarely part of the normal commensal flora. Yet more comprehensive genome-based analyses of the human intestinal microflora suggest that P. aeruginosa is present in up to 20% of normal healthy individuals (Marshall 1991). Although primarily considered to be a nosocomial pathogen that infects the injured and immunocompromised host, P. aeruginosa appears to be the most common cause of infection-related deaths among patients with cystic fibrosis, a genetic disorder of the respiratory epithelium. In this latter host, P. aeruginosa is a chronic colonizer that can persist for many years where it often exerts only moderate virulence.
| Original language | English (US) |
|---|---|
| Title of host publication | Microbial Endocrinology |
| Subtitle of host publication | Interkingdom Signaling in Infectious Disease and Health |
| Publisher | Springer New York |
| Pages | 167-179 |
| Number of pages | 13 |
| ISBN (Electronic) | 9781441955760 |
| ISBN (Print) | 9781441955753 |
| DOIs | |
| State | Published - Jan 1 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
Cite this
The microbial endocrinology of Pseudomonas aeruginosa. / Alverdy, John C.; Romanowski, Kathleen; Zaborina, Olga; Zaborin, Alexander.
Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health. Springer New York, 2010. p. 167-179.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - The microbial endocrinology of Pseudomonas aeruginosa
AU - Alverdy, John C.
AU - Romanowski, Kathleen
AU - Zaborina, Olga
AU - Zaborin, Alexander
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Pseudomonas aeruginosa is a model pathogen with which to advance the notion that microbial endocrinology plays a central role in the pathogenesis of bacteria and other microbes. P. aeruginosa is a gram-negative opportunistic pathogen that can infect a variety of host species, including Arabidopsis, Drosophila, Caenorhabditis elegans, rodents, and man. Like many opportunistic pathogens, virulence expression in P. aeruginosa is not an invariant phenotype. Some investigators consider P. aeruginosa to be an accidental pathogen to man given that it does not appear to have co-evolved with the human immune system; as such it has been assumed to be rarely part of the normal commensal flora. Yet more comprehensive genome-based analyses of the human intestinal microflora suggest that P. aeruginosa is present in up to 20% of normal healthy individuals (Marshall 1991). Although primarily considered to be a nosocomial pathogen that infects the injured and immunocompromised host, P. aeruginosa appears to be the most common cause of infection-related deaths among patients with cystic fibrosis, a genetic disorder of the respiratory epithelium. In this latter host, P. aeruginosa is a chronic colonizer that can persist for many years where it often exerts only moderate virulence.
AB - Pseudomonas aeruginosa is a model pathogen with which to advance the notion that microbial endocrinology plays a central role in the pathogenesis of bacteria and other microbes. P. aeruginosa is a gram-negative opportunistic pathogen that can infect a variety of host species, including Arabidopsis, Drosophila, Caenorhabditis elegans, rodents, and man. Like many opportunistic pathogens, virulence expression in P. aeruginosa is not an invariant phenotype. Some investigators consider P. aeruginosa to be an accidental pathogen to man given that it does not appear to have co-evolved with the human immune system; as such it has been assumed to be rarely part of the normal commensal flora. Yet more comprehensive genome-based analyses of the human intestinal microflora suggest that P. aeruginosa is present in up to 20% of normal healthy individuals (Marshall 1991). Although primarily considered to be a nosocomial pathogen that infects the injured and immunocompromised host, P. aeruginosa appears to be the most common cause of infection-related deaths among patients with cystic fibrosis, a genetic disorder of the respiratory epithelium. In this latter host, P. aeruginosa is a chronic colonizer that can persist for many years where it often exerts only moderate virulence.
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UR - http://www.scopus.com/inward/citedby.url?scp=84919834755&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-5576-0_9
DO - 10.1007/978-1-4419-5576-0_9
M3 - Chapter
AN - SCOPUS:84919834755
SN - 9781441955753
SP - 167
EP - 179
BT - Microbial Endocrinology
PB - Springer New York
ER -