Abstract
Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 310-326 |
| Number of pages | 17 |
| Journal | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
| Volume | 11 |
| DOIs | |
| State | Published - Dec 1 2019 |
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Keywords
- Cerebrovascular disease
- Consortium
- Data harmonization
- Lesion location
- Lesion-symptom mapping
- Small vessel disease
- Stroke
- Support vector regression
- Vascular cognitive impairment
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
Cite this
The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping : Design and multicenter pilot study. / Meta VCI Map consortium; Calgary Normative Study group; Framingham Heart Study group; The Dutch Parelsnoer Institute – Neurodegenerative diseases group; TABASCO group.
In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 01.12.2019, p. 310-326.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping
T2 - Design and multicenter pilot study
AU - Meta VCI Map consortium
AU - Calgary Normative Study group
AU - Framingham Heart Study group
AU - The Dutch Parelsnoer Institute – Neurodegenerative diseases group
AU - TABASCO group
AU - Weaver, Nick A.
AU - Zhao, Lei
AU - Biesbroek, J. Matthijs
AU - Kuijf, Hugo J.
AU - Aben, Hugo P.
AU - Bae, Hee Joon
AU - Caballero, Miguel Á.A.
AU - Chappell, Francesca M.
AU - Chen, Christopher P.L.H.
AU - Dichgans, Martin
AU - Duering, Marco
AU - Georgakis, Marios K.
AU - van der Giessen, Ruben S.
AU - Gyanwali, Bibek
AU - Hamilton, Olivia K.L.
AU - Hilal, Saima
AU - vom Hofe, Elise M.
AU - de Kort, Paul L.M.
AU - Koudstaal, Peter J.
AU - Lam, Bonnie Y.K.
AU - Lim, Jae Sung
AU - Makin, Stephen D.J.
AU - Mok, Vincent C.T.
AU - Shi, Lin
AU - Valdés Hernández, Maria C.
AU - Venketasubramanian, Narayanaswamy
AU - Wardlaw, Joanna M.
AU - Wollenweber, Frank A.
AU - Wong, Adrian
AU - Xin, Xu
AU - DeCarli, Charles
AU - Fletcher, E. A.
AU - Maillard, P.
AU - Barnes, J.
AU - Sudre, C. H.
AU - Schott, J. M.
AU - Ikram, M. A.
AU - Papma, J. M.
AU - Steketee, R. M.E.
AU - Vernooij, M. W.
AU - Bordet, R.
AU - Lopes, R.
AU - Huang, C. W.
AU - Frayne, R.
AU - McCreary, C. R.
AU - Smith, E. E.
AU - Backes, W.
AU - Köhler, S.
AU - van Oostenbrugge, R. J.
AU - Staals, J.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.
AB - Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.
KW - Cerebrovascular disease
KW - Consortium
KW - Data harmonization
KW - Lesion location
KW - Lesion-symptom mapping
KW - Small vessel disease
KW - Stroke
KW - Support vector regression
KW - Vascular cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=85064191398&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064191398&partnerID=8YFLogxK
U2 - 10.1016/j.dadm.2019.02.007
DO - 10.1016/j.dadm.2019.02.007
M3 - Article
AN - SCOPUS:85064191398
VL - 11
SP - 310
EP - 326
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
SN - 2352-8729
ER -