The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study

Meta VCI Map consortium, Calgary Normative Study group, Framingham Heart Study group, The Dutch Parelsnoer Institute – Neurodegenerative diseases group, TABASCO group

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

Original languageEnglish (US)
Pages (from-to)310-326
Number of pages17
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
StatePublished - Dec 1 2019

Fingerprint

Multicenter Studies
Blood Vessels
Meta-Analysis
Stroke
Sample Size
Tomography
Research Personnel
Magnetic Resonance Imaging
Brain
Population
Cognitive Dysfunction
White Matter

Keywords

  • Cerebrovascular disease
  • Consortium
  • Data harmonization
  • Lesion location
  • Lesion-symptom mapping
  • Small vessel disease
  • Stroke
  • Support vector regression
  • Vascular cognitive impairment

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Meta VCI Map consortium, Calgary Normative Study group, Framingham Heart Study group, The Dutch Parelsnoer Institute – Neurodegenerative diseases group, & TABASCO group (2019). The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11, 310-326. https://doi.org/10.1016/j.dadm.2019.02.007

The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping : Design and multicenter pilot study. / Meta VCI Map consortium; Calgary Normative Study group; Framingham Heart Study group; The Dutch Parelsnoer Institute – Neurodegenerative diseases group; TABASCO group.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 01.12.2019, p. 310-326.

Research output: Contribution to journalArticle

Meta VCI Map consortium, Calgary Normative Study group, Framingham Heart Study group, The Dutch Parelsnoer Institute – Neurodegenerative diseases group & TABASCO group 2019, 'The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 11, pp. 310-326. https://doi.org/10.1016/j.dadm.2019.02.007
Meta VCI Map consortium, Calgary Normative Study group, Framingham Heart Study group, The Dutch Parelsnoer Institute – Neurodegenerative diseases group, TABASCO group. The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2019 Dec 1;11:310-326. https://doi.org/10.1016/j.dadm.2019.02.007
Meta VCI Map consortium ; Calgary Normative Study group ; Framingham Heart Study group ; The Dutch Parelsnoer Institute – Neurodegenerative diseases group ; TABASCO group. / The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping : Design and multicenter pilot study. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2019 ; Vol. 11. pp. 310-326.
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T1 - The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping

T2 - Design and multicenter pilot study

AU - Meta VCI Map consortium

AU - Calgary Normative Study group

AU - Framingham Heart Study group

AU - The Dutch Parelsnoer Institute – Neurodegenerative diseases group

AU - TABASCO group

AU - Weaver, Nick A.

AU - Zhao, Lei

AU - Biesbroek, J. Matthijs

AU - Kuijf, Hugo J.

AU - Aben, Hugo P.

AU - Bae, Hee Joon

AU - Caballero, Miguel Á.A.

AU - Chappell, Francesca M.

AU - Chen, Christopher P.L.H.

AU - Dichgans, Martin

AU - Duering, Marco

AU - Georgakis, Marios K.

AU - van der Giessen, Ruben S.

AU - Gyanwali, Bibek

AU - Hamilton, Olivia K.L.

AU - Hilal, Saima

AU - vom Hofe, Elise M.

AU - de Kort, Paul L.M.

AU - Koudstaal, Peter J.

AU - Lam, Bonnie Y.K.

AU - Lim, Jae Sung

AU - Makin, Stephen D.J.

AU - Mok, Vincent C.T.

AU - Shi, Lin

AU - Valdés Hernández, Maria C.

AU - Venketasubramanian, Narayanaswamy

AU - Wardlaw, Joanna M.

AU - Wollenweber, Frank A.

AU - Wong, Adrian

AU - Xin, Xu

AU - DeCarli, Charles

AU - Fletcher, E. A.

AU - Maillard, P.

AU - Barnes, J.

AU - Sudre, C. H.

AU - Schott, J. M.

AU - Ikram, M. A.

AU - Papma, J. M.

AU - Steketee, R. M.E.

AU - Vernooij, M. W.

AU - Bordet, R.

AU - Lopes, R.

AU - Huang, C. W.

AU - Frayne, R.

AU - McCreary, C. R.

AU - Smith, E. E.

AU - Backes, W.

AU - Köhler, S.

AU - van Oostenbrugge, R. J.

AU - Staals, J.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

AB - Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

KW - Cerebrovascular disease

KW - Consortium

KW - Data harmonization

KW - Lesion location

KW - Lesion-symptom mapping

KW - Small vessel disease

KW - Stroke

KW - Support vector regression

KW - Vascular cognitive impairment

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U2 - 10.1016/j.dadm.2019.02.007

DO - 10.1016/j.dadm.2019.02.007

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JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

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SN - 2352-8729

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