The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine specific protein kinases

M. L. Privalsky, R. Ralston, J. M. Bishop

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Avian erythroblastosis virus can transform both fibroblasts and erythroid cells to neoplastic growth. A locus within the virus genome, v-erb B, encodes a membrane glycoprotein essential for the oncogenic properties of the virus. No biochemical function has until now been attributed to the v-erb B protein. We report here that the v-erb B glycoprotein shares strong structural homologie with the tyrosine-specific protein kinase encoded by certain retroviral oncogenes. The patterns of amino acid conservation between the tyrosine-specific protein kinases and the v-erb B protein, and between the v-erb B protein and the catalytic subunit of bovine protein kinase, suggest a possible functional as well as structural relatedness.

Original languageEnglish (US)
Pages (from-to)704-707
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume81
Issue number3 I
StatePublished - 1984
Externally publishedYes

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Membrane Glycoproteins
Oncogenes
Protein-Tyrosine Kinases
Alpharetrovirus
Oncogenic Viruses
Erythroid Cells
Protein Subunits
Protein Kinases
Catalytic Domain
Glycoproteins
Fibroblasts
Genome
Viruses
Amino Acids
Growth
IgA receptor

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine specific protein kinases. / Privalsky, M. L.; Ralston, R.; Bishop, J. M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, No. 3 I, 1984, p. 704-707.

Research output: Contribution to journalArticle

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