Abstract
The medial temporal lobe (MTL) is generally thought to be critical for explicit, but not implicit, memory. Here, we demonstrate that the perirhinal cortex (PRc), within the MTL, plays a role in conceptually-driven implicit memory. Amnesic patients with MTL lesions that converged on the left PRc exhibited deficits on two conceptual implicit tasks (i.e., exemplar generation and semantic decision). A separate functional magnetic resonance imaging (fMRI) study in healthy subjects indicated that PRc activation during encoding of words was predictive of subsequent exemplar generation. Moreover, across subjects, the magnitude of the fMRI and behavioral conceptual priming effects were directly related. Additionally, the PRc region implicated in the fMRI study was the same region of maximal lesion overlap in the patients with impaired conceptual priming. These patient and imaging results converge to suggest that the PRc plays a critical role in conceptual implicit memory, and possibly conceptual processing in general.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 835-842 |
| Number of pages | 8 |
| Journal | Neuron |
| Volume | 68 |
| Issue number | 5 |
| DOIs | |
| State | Published - Dec 9 2010 |
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ASJC Scopus subject areas
- Neuroscience(all)
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The Medial Temporal Lobe Supports Conceptual Implicit Memory. / Wang, Wei Chun; Lazzara, Michele M.; Ranganath, Charan; Knight, Robert T.; Yonelinas, Andrew P.
In: Neuron, Vol. 68, No. 5, 09.12.2010, p. 835-842.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Medial Temporal Lobe Supports Conceptual Implicit Memory
AU - Wang, Wei Chun
AU - Lazzara, Michele M.
AU - Ranganath, Charan
AU - Knight, Robert T.
AU - Yonelinas, Andrew P.
PY - 2010/12/9
Y1 - 2010/12/9
N2 - The medial temporal lobe (MTL) is generally thought to be critical for explicit, but not implicit, memory. Here, we demonstrate that the perirhinal cortex (PRc), within the MTL, plays a role in conceptually-driven implicit memory. Amnesic patients with MTL lesions that converged on the left PRc exhibited deficits on two conceptual implicit tasks (i.e., exemplar generation and semantic decision). A separate functional magnetic resonance imaging (fMRI) study in healthy subjects indicated that PRc activation during encoding of words was predictive of subsequent exemplar generation. Moreover, across subjects, the magnitude of the fMRI and behavioral conceptual priming effects were directly related. Additionally, the PRc region implicated in the fMRI study was the same region of maximal lesion overlap in the patients with impaired conceptual priming. These patient and imaging results converge to suggest that the PRc plays a critical role in conceptual implicit memory, and possibly conceptual processing in general.
AB - The medial temporal lobe (MTL) is generally thought to be critical for explicit, but not implicit, memory. Here, we demonstrate that the perirhinal cortex (PRc), within the MTL, plays a role in conceptually-driven implicit memory. Amnesic patients with MTL lesions that converged on the left PRc exhibited deficits on two conceptual implicit tasks (i.e., exemplar generation and semantic decision). A separate functional magnetic resonance imaging (fMRI) study in healthy subjects indicated that PRc activation during encoding of words was predictive of subsequent exemplar generation. Moreover, across subjects, the magnitude of the fMRI and behavioral conceptual priming effects were directly related. Additionally, the PRc region implicated in the fMRI study was the same region of maximal lesion overlap in the patients with impaired conceptual priming. These patient and imaging results converge to suggest that the PRc plays a critical role in conceptual implicit memory, and possibly conceptual processing in general.
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U2 - 10.1016/j.neuron.2010.11.009
DO - 10.1016/j.neuron.2010.11.009
M3 - Article
VL - 68
SP - 835
EP - 842
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 5
ER -