The Medial Temporal Lobe Supports Conceptual Implicit Memory

Wei Chun Wang, Michele M. Lazzara, Charan Ranganath, Robert T. Knight, Andrew P. Yonelinas

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The medial temporal lobe (MTL) is generally thought to be critical for explicit, but not implicit, memory. Here, we demonstrate that the perirhinal cortex (PRc), within the MTL, plays a role in conceptually-driven implicit memory. Amnesic patients with MTL lesions that converged on the left PRc exhibited deficits on two conceptual implicit tasks (i.e., exemplar generation and semantic decision). A separate functional magnetic resonance imaging (fMRI) study in healthy subjects indicated that PRc activation during encoding of words was predictive of subsequent exemplar generation. Moreover, across subjects, the magnitude of the fMRI and behavioral conceptual priming effects were directly related. Additionally, the PRc region implicated in the fMRI study was the same region of maximal lesion overlap in the patients with impaired conceptual priming. These patient and imaging results converge to suggest that the PRc plays a critical role in conceptual implicit memory, and possibly conceptual processing in general.

Original languageEnglish (US)
Pages (from-to)835-842
Number of pages8
JournalNeuron
Volume68
Issue number5
DOIs
StatePublished - Dec 9 2010

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Temporal Lobe
Magnetic Resonance Imaging
Semantics
Healthy Volunteers
Perirhinal Cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wang, W. C., Lazzara, M. M., Ranganath, C., Knight, R. T., & Yonelinas, A. P. (2010). The Medial Temporal Lobe Supports Conceptual Implicit Memory. Neuron, 68(5), 835-842. https://doi.org/10.1016/j.neuron.2010.11.009

The Medial Temporal Lobe Supports Conceptual Implicit Memory. / Wang, Wei Chun; Lazzara, Michele M.; Ranganath, Charan; Knight, Robert T.; Yonelinas, Andrew P.

In: Neuron, Vol. 68, No. 5, 09.12.2010, p. 835-842.

Research output: Contribution to journalArticle

Wang, WC, Lazzara, MM, Ranganath, C, Knight, RT & Yonelinas, AP 2010, 'The Medial Temporal Lobe Supports Conceptual Implicit Memory', Neuron, vol. 68, no. 5, pp. 835-842. https://doi.org/10.1016/j.neuron.2010.11.009
Wang WC, Lazzara MM, Ranganath C, Knight RT, Yonelinas AP. The Medial Temporal Lobe Supports Conceptual Implicit Memory. Neuron. 2010 Dec 9;68(5):835-842. https://doi.org/10.1016/j.neuron.2010.11.009
Wang, Wei Chun ; Lazzara, Michele M. ; Ranganath, Charan ; Knight, Robert T. ; Yonelinas, Andrew P. / The Medial Temporal Lobe Supports Conceptual Implicit Memory. In: Neuron. 2010 ; Vol. 68, No. 5. pp. 835-842.
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