The medial and lateral entorhinal cortex both contribute to contextual and item recognition memory: A test of the binding ofitems and context model

Michael R. Hunsaker, Victoria Chen, Giang T. Tran, Raymond P. Kesner

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

It has been suggested that the role of the hippocampus for episodic memory is to selectively bind together item and contextual information. One such model, the Binding of Items and Context (BIC) model, proposed that the perirhinal cortex provides item and the postrhinal/parahippocampal cortex provides context to the hippocampus via the medial (MEC) and lateral entorhinal cortices (LEC) to be bound into an episodic representation. This model proposes that item and context information are stored and processed independently and in parallel before hippocampal processing. To evaluate this model, the present experiment evaluated the role of the MEC and LEC for item and contextual novelty detection. The present results suggest that excitotoxic lesions to the LEC primarily disrupt item novelty detection, whereas lesions to the MEC primarily disrupt contextual novelty detection. These data provide a functional double dissociation between the MEC and LEC across item and contextual processing. Despite this dissociation, the present results suggest that item and contextual information are not represented independently before hippocampal processing. These data support the basic assumptions of the BIC model, but suggest that item and context information may interact in the entorhinal cortex.

Original languageEnglish (US)
Pages (from-to)380-391
Number of pages12
JournalHippocampus
Volume23
Issue number5
DOIs
StatePublished - May 2013

Fingerprint

Entorhinal Cortex
Hippocampus
Episodic Memory
Recognition (Psychology)

Keywords

  • Contextual discrimination
  • Lateral entorhinal cortex
  • Medial entorhinal cortex
  • Novelty detection
  • Theoretical model

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

The medial and lateral entorhinal cortex both contribute to contextual and item recognition memory : A test of the binding ofitems and context model. / Hunsaker, Michael R.; Chen, Victoria; Tran, Giang T.; Kesner, Raymond P.

In: Hippocampus, Vol. 23, No. 5, 05.2013, p. 380-391.

Research output: Contribution to journalArticle

Hunsaker, Michael R. ; Chen, Victoria ; Tran, Giang T. ; Kesner, Raymond P. / The medial and lateral entorhinal cortex both contribute to contextual and item recognition memory : A test of the binding ofitems and context model. In: Hippocampus. 2013 ; Vol. 23, No. 5. pp. 380-391.
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