Allogeneic transplantation of coarse powders of the rat calvarial matrix to subcutaneous spaces resulted in transformation of fibroblasts to chondroblasts and osteoblasts. The emergence of new phenotypes was quantitated by determination of alkaline phosphatase activity and 45Ca incorporation. A comparison of the matrices from rat calvarium and diaphyseal bone revealed that matrix of the shaft of long bones is more potent as transformant than matrix of the vault of the skull.
|Original language||English (US)|
|Number of pages||3|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Nov 1975|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)