Abstract
The sister biastomeres ABp and ABa are equipotent at the beginning of the 4-cell stage in C. elegans embryos, but soon become committed to different fates. We show that the glp-1 gene, a homolog of the Notch gene of Drosophila, functions in two distinct cell-cell interactions that specify the ABp and ABa fates. These interactions both require maternal expression of glp-1. We show that a second maternal gene, apx-1, functions with glp-1 only in the specification of the ABp fate and that apx-1 can encode a protein homologous to the Delta protein of Drosophila. Our results suggest how interactions mediated by glp-1 and apx-1 contribute to the establishment of the dorsal-ventral axis in the early C. elegans embryo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 95-106 |
| Number of pages | 12 |
| Journal | Cell |
| Volume | 77 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 8 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
Cite this
The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo. / Mello, Cralg C.; Draper, Bruce W.; Prless, James R.
In: Cell, Vol. 77, No. 1, 08.04.1994, p. 95-106.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo
AU - Mello, Cralg C.
AU - Draper, Bruce W.
AU - Prless, James R.
PY - 1994/4/8
Y1 - 1994/4/8
N2 - The sister biastomeres ABp and ABa are equipotent at the beginning of the 4-cell stage in C. elegans embryos, but soon become committed to different fates. We show that the glp-1 gene, a homolog of the Notch gene of Drosophila, functions in two distinct cell-cell interactions that specify the ABp and ABa fates. These interactions both require maternal expression of glp-1. We show that a second maternal gene, apx-1, functions with glp-1 only in the specification of the ABp fate and that apx-1 can encode a protein homologous to the Delta protein of Drosophila. Our results suggest how interactions mediated by glp-1 and apx-1 contribute to the establishment of the dorsal-ventral axis in the early C. elegans embryo.
AB - The sister biastomeres ABp and ABa are equipotent at the beginning of the 4-cell stage in C. elegans embryos, but soon become committed to different fates. We show that the glp-1 gene, a homolog of the Notch gene of Drosophila, functions in two distinct cell-cell interactions that specify the ABp and ABa fates. These interactions both require maternal expression of glp-1. We show that a second maternal gene, apx-1, functions with glp-1 only in the specification of the ABp fate and that apx-1 can encode a protein homologous to the Delta protein of Drosophila. Our results suggest how interactions mediated by glp-1 and apx-1 contribute to the establishment of the dorsal-ventral axis in the early C. elegans embryo.
UR - http://www.scopus.com/inward/record.url?scp=0028283996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028283996&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(94)90238-0
DO - 10.1016/0092-8674(94)90238-0
M3 - Article
C2 - 8156602
AN - SCOPUS:0028283996
VL - 77
SP - 95
EP - 106
JO - Cell
JF - Cell
SN - 0092-8674
IS - 1
ER -