The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo

Cralg C. Mello, Bruce W. Draper, James R. Prless

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

The sister biastomeres ABp and ABa are equipotent at the beginning of the 4-cell stage in C. elegans embryos, but soon become committed to different fates. We show that the glp-1 gene, a homolog of the Notch gene of Drosophila, functions in two distinct cell-cell interactions that specify the ABp and ABa fates. These interactions both require maternal expression of glp-1. We show that a second maternal gene, apx-1, functions with glp-1 only in the specification of the ABp fate and that apx-1 can encode a protein homologous to the Delta protein of Drosophila. Our results suggest how interactions mediated by glp-1 and apx-1 contribute to the establishment of the dorsal-ventral axis in the early C. elegans embryo.

Original languageEnglish (US)
Pages (from-to)95-106
Number of pages12
JournalCell
Volume77
Issue number1
DOIs
StatePublished - Apr 8 1994
Externally publishedYes

Fingerprint

Embryonic Structures
Genes
Mothers
Cell Communication
Drosophila
Specifications
Proteins
delta protein

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo. / Mello, Cralg C.; Draper, Bruce W.; Prless, James R.

In: Cell, Vol. 77, No. 1, 08.04.1994, p. 95-106.

Research output: Contribution to journalArticle

Mello, Cralg C. ; Draper, Bruce W. ; Prless, James R. / The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo. In: Cell. 1994 ; Vol. 77, No. 1. pp. 95-106.
@article{aa560cd2dc074583b73cc0d022933a53,
title = "The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo",
abstract = "The sister biastomeres ABp and ABa are equipotent at the beginning of the 4-cell stage in C. elegans embryos, but soon become committed to different fates. We show that the glp-1 gene, a homolog of the Notch gene of Drosophila, functions in two distinct cell-cell interactions that specify the ABp and ABa fates. These interactions both require maternal expression of glp-1. We show that a second maternal gene, apx-1, functions with glp-1 only in the specification of the ABp fate and that apx-1 can encode a protein homologous to the Delta protein of Drosophila. Our results suggest how interactions mediated by glp-1 and apx-1 contribute to the establishment of the dorsal-ventral axis in the early C. elegans embryo.",
author = "Mello, {Cralg C.} and Draper, {Bruce W.} and Prless, {James R.}",
year = "1994",
month = "4",
day = "8",
doi = "10.1016/0092-8674(94)90238-0",
language = "English (US)",
volume = "77",
pages = "95--106",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo

AU - Mello, Cralg C.

AU - Draper, Bruce W.

AU - Prless, James R.

PY - 1994/4/8

Y1 - 1994/4/8

N2 - The sister biastomeres ABp and ABa are equipotent at the beginning of the 4-cell stage in C. elegans embryos, but soon become committed to different fates. We show that the glp-1 gene, a homolog of the Notch gene of Drosophila, functions in two distinct cell-cell interactions that specify the ABp and ABa fates. These interactions both require maternal expression of glp-1. We show that a second maternal gene, apx-1, functions with glp-1 only in the specification of the ABp fate and that apx-1 can encode a protein homologous to the Delta protein of Drosophila. Our results suggest how interactions mediated by glp-1 and apx-1 contribute to the establishment of the dorsal-ventral axis in the early C. elegans embryo.

AB - The sister biastomeres ABp and ABa are equipotent at the beginning of the 4-cell stage in C. elegans embryos, but soon become committed to different fates. We show that the glp-1 gene, a homolog of the Notch gene of Drosophila, functions in two distinct cell-cell interactions that specify the ABp and ABa fates. These interactions both require maternal expression of glp-1. We show that a second maternal gene, apx-1, functions with glp-1 only in the specification of the ABp fate and that apx-1 can encode a protein homologous to the Delta protein of Drosophila. Our results suggest how interactions mediated by glp-1 and apx-1 contribute to the establishment of the dorsal-ventral axis in the early C. elegans embryo.

UR - http://www.scopus.com/inward/record.url?scp=0028283996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028283996&partnerID=8YFLogxK

U2 - 10.1016/0092-8674(94)90238-0

DO - 10.1016/0092-8674(94)90238-0

M3 - Article

C2 - 8156602

AN - SCOPUS:0028283996

VL - 77

SP - 95

EP - 106

JO - Cell

JF - Cell

SN - 0092-8674

IS - 1

ER -