The mannose receptor mediates the cellular immune response in human coccidioidomycosis

Neil M. Ampel, Daniel K. Nelson, Lijin Li, Sara O. Dionne, Douglas F. Lake, Keira A. Simmons, Demosthenes Pappagianis

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Mannose is the predominant monosaccharide in the coccidioidal antigen preparation T27K. Mannan and anti-CD206 antibody significantly decreased the surface expression of mannose receptor (MR) on adherent peripheral blood mononuclear cells and reduced the interleukin-2 (IL-2) release induced by T27K. These data suggest that MR mediates IL-2 release by T27K.

Original languageEnglish (US)
Pages (from-to)2554-2555
Number of pages2
JournalInfection and Immunity
Volume73
Issue number4
DOIs
StatePublished - Apr 2005

ASJC Scopus subject areas

  • Immunology

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