The mammary pathology of genetically engineered mice: The consensus report and recommendations from the Annapolis meeting

Robert Cardiff, Miriam R. Anver, Barry A. Gusterson, Lothar Hennighausen, Roy A. Jensen, Maria J. Merino, Sabine Rehm, Jose Russo, Fattaneh A. Tavassoli, Lalage M. Wakefield, Jerrold M. Ward, Jeffrey E. Green

Research output: Contribution to journalArticle

369 Citations (Scopus)

Abstract

NIH sponsored a meeting of medical and veterinary pathologists with mammary gland expertise in Annapolis in March 1999. Rapid development of mouse mammary models has accentuated the need for definitions of the mammary lesions in genetically engineered mice (GEM) and to assess their usefulness as models of human breast disease. The panel of nine pathologists independently reviewed material representing over 90% of the published systems. The GEM tumors were found to have: (1) phenotypes similar to those of non-GEM; (2) signature phenotypes specific to the transgene; and (3) some morphological similarities to the human disease. The current mouse mammary and human breast tumor classifications describe the majority of GEM lesions but unique morphologic lesions are found in many GEM. Since little information is available on the natural history of GEM lesions, a simple morphologic nomenclature is proposed that allows direct comparisons between models. Future progress requires rigorous application of guidelines covering pathologic examination of the mammary gland and the whole animal. Since the phenotype of the lesions is an essential component of their molecular pathology, funding agencies should adopt policies ensuring careful morphological evaluation of any funded research involving animal models. A pathologist should be part of each research team.

Original languageEnglish (US)
Pages (from-to)968-988
Number of pages21
JournalOncogene
Volume19
Issue number8
DOIs
StatePublished - Feb 21 2000

Fingerprint

Breast
Pathology
Phenotype
Animal Mammary Glands
Breast Diseases
Molecular Pathology
Human Mammary Glands
Natural History
Transgenes
Research
Terminology
Animal Models
Guidelines
Breast Neoplasms
Pathologists
Neoplasms

Keywords

  • Breast tumor classifications
  • Genetically engineered mice
  • Mouse mammary models

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Cardiff, R., Anver, M. R., Gusterson, B. A., Hennighausen, L., Jensen, R. A., Merino, M. J., ... Green, J. E. (2000). The mammary pathology of genetically engineered mice: The consensus report and recommendations from the Annapolis meeting. Oncogene, 19(8), 968-988. https://doi.org/10.1038/sj.onc.1203277

The mammary pathology of genetically engineered mice : The consensus report and recommendations from the Annapolis meeting. / Cardiff, Robert; Anver, Miriam R.; Gusterson, Barry A.; Hennighausen, Lothar; Jensen, Roy A.; Merino, Maria J.; Rehm, Sabine; Russo, Jose; Tavassoli, Fattaneh A.; Wakefield, Lalage M.; Ward, Jerrold M.; Green, Jeffrey E.

In: Oncogene, Vol. 19, No. 8, 21.02.2000, p. 968-988.

Research output: Contribution to journalArticle

Cardiff, R, Anver, MR, Gusterson, BA, Hennighausen, L, Jensen, RA, Merino, MJ, Rehm, S, Russo, J, Tavassoli, FA, Wakefield, LM, Ward, JM & Green, JE 2000, 'The mammary pathology of genetically engineered mice: The consensus report and recommendations from the Annapolis meeting', Oncogene, vol. 19, no. 8, pp. 968-988. https://doi.org/10.1038/sj.onc.1203277
Cardiff, Robert ; Anver, Miriam R. ; Gusterson, Barry A. ; Hennighausen, Lothar ; Jensen, Roy A. ; Merino, Maria J. ; Rehm, Sabine ; Russo, Jose ; Tavassoli, Fattaneh A. ; Wakefield, Lalage M. ; Ward, Jerrold M. ; Green, Jeffrey E. / The mammary pathology of genetically engineered mice : The consensus report and recommendations from the Annapolis meeting. In: Oncogene. 2000 ; Vol. 19, No. 8. pp. 968-988.
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