The Mammary Fat Pad

Margaret C. Neville, Daniel Medina, Jenifer Monks, Russel C. Hovey

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

The mammary fat pad is essential for development of the mammary epithelium, providing signals that mediate ductal morphogenesis and, probably, alveolar differentiation. The "cleared" fat pad is often used as a transplantation site. Considering the crucial role of the fat pad, its properties have received relatively little attention from researchers in the field. Some of the questions whose investigation is pertinent to understanding both normal mammary development and carcinogenesis are outlined in this commentary in the spirit of stimulating enquiry into this important subject. It is clear from a brief perusal of the available literature that until studies are specifically designed to clearly differentiate between functional effects of the fibrous and the adipose stroma, more substantive information about their differential effects on mammary development and tumorigenesis will not be forthcoming.

Original languageEnglish (US)
Pages (from-to)109-116
Number of pages8
JournalJournal of Mammary Gland Biology and Neoplasia
Volume3
Issue number2
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research

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    Neville, M. C., Medina, D., Monks, J., & Hovey, R. C. (1998). The Mammary Fat Pad. Journal of Mammary Gland Biology and Neoplasia, 3(2), 109-116.