The mammalian gene function resource: The International Knockout Mouse Consortium

Allan Bradley, Konstantinos Anastassiadis, Abdelkader Ayadi, James F. Battey, Cindy Bell, Marie Christine Birling, Joanna Bottomley, Steve D. Brown, Antje Bürger, Carol J. Bult, Wendy Bushell, Francis S. Collins, Christian Desaintes, Brendan Doe, Economides Aris, Janan T. Eppig, Richard H. Finnell, Colin Fletcher, Martin Fray, David FrendeweyRoland H. Friedel, Frank G. Grosveld, Jens Hansen, Yann Hérault, Geoffrey Hicks, Andreas Hörlein, Richard Houghton, Martin Hrabé De Angelis, Danny Huylebroeck, Vivek Iyer, Pieter J. De Jong, James A. Kadin, Cornelia Kaloff, Karen Kennedy, Manousos Koutsourakis, Kevin C K Lloyd, Susan Marschall, Jeremy Mason, Colin McKerlie, Michael P. McLeod, Harald Von Melchner, Mark Moore, Alejandro O. Mujica, Andras Nagy, Mikhail Nefedov, Lauryl M. Nutter, Guillaume Pavlovic, Jane L. Peterson, Jonathan Pollock, Ramiro Ramirez-Solis, Derrick E. Rancourt, Marcello Raspa, Jacques E. Remacle, Martin Ringwald, Barry Rosen, Nadia Rosenthal, Janet Rossant, Patricia Ruiz Noppinger, Ed Ryder, Joel Zupicich Schick, Frank Schnütgen, Paul Schofield, Claudia Seisenberger, Mohammed Selloum, Elizabeth M. Simpson, William C. Skarnes, Damian Smedley, William L. Stanford, A. Francis Stewart, Kevin Stone, Kate Swan, Hamsa Tadepally, Lydia Teboul, Glauco P. Tocchini-Valentini, David Valenzuela, Anthony P. West, Ken Ichi Yamamura, Yuko Yoshinaga, Wolfgang Wurst

Research output: Contribution to journalArticlepeer-review

173 Scopus citations

Abstract

In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed highthroughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

Original languageEnglish (US)
Pages (from-to)580-586
Number of pages7
JournalMammalian Genome
Volume23
Issue number9-10
DOIs
StatePublished - Oct 2012

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'The mammalian gene function resource: The International Knockout Mouse Consortium'. Together they form a unique fingerprint.

Cite this