The macrophage in the persistence and pathogenesis of HIV infection

H. E. Gendelman, J. M. Orenstein, L. M. Baca, Barbara Weiser, Harold Burger, D. C. Kalter, M. S. Meltzer

Research output: Contribution to journalArticle

290 Scopus citations

Abstract

Infection of mononuclear phagocyte lineage cells with HIV results in a persistent productive infection despite an often vigorous, and usually ineffective, host-cell immune response. Ultimately, most infected individuals develop immunologic and neurologic abnormalities leading to OI and cognitive brain dysfunction. The development of effective means to prevent and treat HIV infection in humans will depend on a better understanding of the interactions of HIV and the macrophage, a reservoir for infection and vehicle for dissemination of virus in the human host.

Original languageEnglish (US)
Pages (from-to)475-495
Number of pages21
JournalAIDS
Volume3
Issue number8
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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  • Cite this

    Gendelman, H. E., Orenstein, J. M., Baca, L. M., Weiser, B., Burger, H., Kalter, D. C., & Meltzer, M. S. (1989). The macrophage in the persistence and pathogenesis of HIV infection. AIDS, 3(8), 475-495.