Infection of mononuclear phagocyte lineage cells with HIV results in a persistent productive infection despite an often vigorous, and usually ineffective, host-cell immune response. Ultimately, most infected individuals develop immunologic and neurologic abnormalities leading to OI and cognitive brain dysfunction. The development of effective means to prevent and treat HIV infection in humans will depend on a better understanding of the interactions of HIV and the macrophage, a reservoir for infection and vehicle for dissemination of virus in the human host.
|Original language||English (US)|
|Number of pages||21|
|State||Published - 1989|
ASJC Scopus subject areas
- Immunology and Allergy