The macaque model for in vitro fertilization: superovulation techniques and ultrasound-guided follicular aspiration.

C. A. VandeVoort, Alice F Tarantal

Research output: Contribution to journalArticle

46 Scopus citations


Prior methods for macaque in vitro fertilization (IVF) have incorporated laparoscopy and/or laparotomy as the primary means for oocyte recovery. Sonographic techniques, as used with human IVF, have been applied to the macaque, both for monitoring the response to hyperstimulation and for follicular aspiration prior to ovulation. Pergonal (hMG) was administered for 7 or 8 days beginning on cycle day 1 or 2 or for 6 days beginning on cycle day 3. This was followed by Pregnyl (hCG) prior to follicular aspiration. The quality of oocytes recovered from the 6-day treatment group was considerably better than those treated for greater than or equal to 7 days. It was concluded that ultrasound can provide a reliable means for documenting the response to ovarian stimulation and the successful transabdominal aspiration of multiple follicles.

Original languageEnglish (US)
Pages (from-to)110-116
Number of pages7
JournalJournal of Medical Primatology
Issue number3
StatePublished - May 1991


ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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