The low plasma testosterone levels of young Indian infarct survivors are not due to a primary testicular defect

M. Sewdarsen, I. Jialal, R. K. Naidu

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A case control study was performed to determine whether the hypotestosteronaemia described in men with coronary artery disease could be the result of primary testicular dysfunction. Testicular function was assessed by comparing the response of 10 young Indian men with myocardial infarction to human chorionic gonadotrophin (HCG) injection to that of 10 healthy age and weight matched controls. The basal testosterone levels in the patients were significantly lower (12.71 + 1.36 nmol/l vs 16.51+0.79nmol/l; P=0.01) and the basal oestradiol levels significantly higher than the controls (120.67+8.81pmol/1 vs 94.05±8.23pmol/l; P=0.02). There was no difference in the sex hormone binding globulin concentrations. However, following HCG stimulation the patients demonstrated a normal response with a 2-fold increase in testosterone. There was no difference in the testosterone and oestradiol levels of the patients and controls following HCG stimulation. This normal response in our patients demonstrates that the hypotestosteronaemia in Indian men with myocardial infarction is not due to a primary testicular dysfunction but probably is a result of increased aromatization of testosterone to oestradiol.

Original languageEnglish (US)
Pages (from-to)264-266
Number of pages3
JournalPostgraduate Medical Journal
Volume64
Issue number750
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Medicine(all)

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