The longevity of immunoglobulin preservation in canine skin utilizing Michel's fixative

Peter J. Ihrke, Anthony A. Stannard, Alex Ardans, Sharon G. Yaskulski

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Skin biopsy specimens from 7 dogs with immune-mediated skin diseases diagnosed by routine histology and 5 dogs with other skin diseases were placed in Michel's transport medium for 4 to 9 years. Direct immunofluorescence yielded positive results in tissue samples from 3 dogs with pemphigus foliaceus and 2 dogs with discoid lupus erythematosus. Direct immunofluorescence was not seen in tissue samples from 1 dog with pemphigus foliaceus and 5 dogs with non immune-mediated skin diseases. Direct immunofluorescence was seen in skin biopsy specimens maintained in Michel's medium for 4 to 8 years.

Original languageEnglish (US)
Pages (from-to)161-170
Number of pages10
JournalVeterinary Immunology and Immunopathology
Volume9
Issue number2
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

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