Abstract
Histologic clues that facilitate rapid diagnosis of morphea at scanning magnification have been described but not well studied. We examined 73 cases of morphea and 42 control cases to determine the sensitivity and specificity of a novel histopathological feature-"the line sign (LS)"-a prominent, straight interface between subcutis and adjacent collagen. The sensitivity of LS was shown to be the most sensitive feature among 4 other existing histopathological features. Its specificity, however, was not the highest among the other features and needs to be evaluated further in future studies to confirm the usefulness of LS as a diagnostic tool for morphea.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 873-878 |
| Number of pages | 6 |
| Journal | The American Journal of dermatopathology |
| Volume | 40 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2018 |
Fingerprint
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Dermatology
Cite this
The "Line Sign" Is a Rapid and Efficient Diagnostic "Test" for Morphea : Clinicopathological Study of 73 Cases. / Yang, Sarah; Draznin, Michelle; Fung, Maxwell A.
In: The American Journal of dermatopathology, Vol. 40, No. 12, 01.12.2018, p. 873-878.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The "Line Sign" Is a Rapid and Efficient Diagnostic "Test" for Morphea
T2 - Clinicopathological Study of 73 Cases
AU - Yang, Sarah
AU - Draznin, Michelle
AU - Fung, Maxwell A
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Histologic clues that facilitate rapid diagnosis of morphea at scanning magnification have been described but not well studied. We examined 73 cases of morphea and 42 control cases to determine the sensitivity and specificity of a novel histopathological feature-"the line sign (LS)"-a prominent, straight interface between subcutis and adjacent collagen. The sensitivity of LS was shown to be the most sensitive feature among 4 other existing histopathological features. Its specificity, however, was not the highest among the other features and needs to be evaluated further in future studies to confirm the usefulness of LS as a diagnostic tool for morphea.
AB - Histologic clues that facilitate rapid diagnosis of morphea at scanning magnification have been described but not well studied. We examined 73 cases of morphea and 42 control cases to determine the sensitivity and specificity of a novel histopathological feature-"the line sign (LS)"-a prominent, straight interface between subcutis and adjacent collagen. The sensitivity of LS was shown to be the most sensitive feature among 4 other existing histopathological features. Its specificity, however, was not the highest among the other features and needs to be evaluated further in future studies to confirm the usefulness of LS as a diagnostic tool for morphea.
UR - http://www.scopus.com/inward/record.url?scp=85057127820&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057127820&partnerID=8YFLogxK
U2 - 10.1097/DAD.0000000000001177
DO - 10.1097/DAD.0000000000001177
M3 - Article
C2 - 30475273
AN - SCOPUS:85057127820
VL - 40
SP - 873
EP - 878
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
SN - 0193-1091
IS - 12
ER -