The lens in focus: A comparison of lens development in Drosophila and vertebrates

Mark Charlton-Perkins, Nadean L Brown, Tiffany A. Cook

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The evolution of the eye has been a major subject of study dating back centuries. The advent of molecular genetics offered the surprising finding that morphologically distinct eyes rely on conserved regulatory gene networks for their formation. While many of these advances often stemmed from studies of the compound eye of the fruit fly, Drosophila melanogaster, and later translated to discoveries in vertebrate systems, studies on vertebrate lens development far outnumber those in Drosophila. This may be largely historical, since Spemann and Mangold's paradigm of tissue induction was discovered in the amphibian lens. Recent studies on lens development in Drosophila have begun to define molecular commonalities with the vertebrate lens. Here, we provide an overview of Drosophila lens development, discussing intrinsic and extrinsic factors controlling lens cell specification and differentiation. We then summarize key morphological and molecular events in vertebrate lens development, emphasizing regulatory factors and networks strongly associated with both systems. Finally, we provide a comparative analysis that highlights areas of research that would help further clarify the degree of conservation between the formation of dioptric systems in invertebrates and vertebrates.

Original languageEnglish (US)
Pages (from-to)189-213
Number of pages25
JournalMolecular Genetics and Genomics
Volume286
Issue number3-4
DOIs
StatePublished - Oct 2011
Externally publishedYes

Fingerprint

Lenses
Drosophila
Vertebrates
Intrinsic Factor
Gene Regulatory Networks
Amphibians
Invertebrates
Drosophila melanogaster
Diptera
Molecular Biology
Cell Differentiation
Fruit
Research

Keywords

  • Cone cell
  • Corneagenous
  • Corneal lens
  • Fiber cell
  • Semper cell

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology

Cite this

The lens in focus : A comparison of lens development in Drosophila and vertebrates. / Charlton-Perkins, Mark; Brown, Nadean L; Cook, Tiffany A.

In: Molecular Genetics and Genomics, Vol. 286, No. 3-4, 10.2011, p. 189-213.

Research output: Contribution to journalArticle

Charlton-Perkins, Mark ; Brown, Nadean L ; Cook, Tiffany A. / The lens in focus : A comparison of lens development in Drosophila and vertebrates. In: Molecular Genetics and Genomics. 2011 ; Vol. 286, No. 3-4. pp. 189-213.
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