The late effects of radiation on the blood brain barrier

Michael P. Remler, William H. Marcussen, Janice Tiller-Borsich

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Rats were irradiated with 60 to 20 Gy in a single dose focussed to a volume of 0.5 cc in the center of the left hemisphere. Breakdown of the BBB was detected by (a) the presence of spikes on EEG after subcutaneous injection of Bicuculline methiodide, and (b) the presence of staining following Evans Blue dye injection. Breakdown of the BBB (mean and standard deviation) occurred in 38 46 of the 60 Gy rats at 98 ± 16 days, 7 11 of the 50 Gy rats at 128 ± 25 days, 11 18 of the 40 Gy rats at 162 ± 3 days, 5 11 of the 30 Gy rats at 178 ± 5 days and, 7 12 of the 20 Gy rats at 217 ± 7 days post irradiation. This study suggests that endothelial damage could be the principle mechanism mediating the late radiation syndrome.

Original languageEnglish (US)
Pages (from-to)1965-1969
Number of pages5
JournalInternational Journal of Radiation Oncology, Biology, Physics
Issue number11
StatePublished - 1986


  • Blood-brain barrier
  • CNS
  • Endothelium
  • Radiation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation


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