The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice

Angela Franciska Haczku, Elena N. Atochina, Yaniv Tomer, Yang Cao, Colleen Campbell, Seth T. Scanlon, Scott J. Russo, Goran Enhorning, Michael F. Beers

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Pulmonary surfactant dysfunction may significantly contribute to small airway obstruction during the asthmatic response, but neither its exact role nor its regulation is clear. Surfactant function and composition was studied in an Aspergillus fumigatus (Af)-induced late-phase allergic airway response in sensitized BALB/c mice. The peak of Af-induced airway hyperresponsiveness in sensitized and challenged mice 24 h after allergen provocation coincided with a significant fall in surface activity of the pulmonary surfactant. The underlying changes included time-dependent elaboration of eotaxin and IL-5 followed by eosinophil influx into the airways. The height of airway inflammation and hyperresponsiveness was preceded by release of IL-4 and marked reductions in surfactant protein (SP)-B, a hydrophobic surfactant protein responsible for maintaining low surface tension of the lining fluid of distal air spaces. Furthermore, intratracheal administration of IL-4 significantly inhibited SP-B, indicating a regulatory role of this cytokine in the surfactant biophysical changes. Thus surfactant dysfunction induced by an IL-4-driven SP-B deficiency after allergen provocation may be an important part of the late asthmatic airway response.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume283
Issue number4 27-4
StatePublished - Oct 2002
Externally publishedYes

Fingerprint

Surface Tension
Surface-Active Agents
Interleukin-4
Pulmonary Surfactants
Aspergillus fumigatus
Allergens
Interleukin-5
Airway Obstruction
Eosinophils
Air
IgA receptor
Cytokines
Inflammation
Proteins

Keywords

  • Allergy
  • Aspergillus fumigatus
  • Asthma
  • Surfactant proteins

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Cell Biology
  • Physiology (medical)

Cite this

The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice. / Haczku, Angela Franciska; Atochina, Elena N.; Tomer, Yaniv; Cao, Yang; Campbell, Colleen; Scanlon, Seth T.; Russo, Scott J.; Enhorning, Goran; Beers, Michael F.

In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 283, No. 4 27-4, 10.2002.

Research output: Contribution to journalArticle

Haczku, AF, Atochina, EN, Tomer, Y, Cao, Y, Campbell, C, Scanlon, ST, Russo, SJ, Enhorning, G & Beers, MF 2002, 'The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 283, no. 4 27-4.
Haczku, Angela Franciska ; Atochina, Elena N. ; Tomer, Yaniv ; Cao, Yang ; Campbell, Colleen ; Scanlon, Seth T. ; Russo, Scott J. ; Enhorning, Goran ; Beers, Michael F. / The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice. In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 2002 ; Vol. 283, No. 4 27-4.
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