Abstract
In the rat dieldrin can evoke a progressive increase in the severity of convulsive responses (kindling) during repetitive exposures that cannot be attributed to simple accumulation of dieldrin in the brain. It can also replace pentylenetetrazol as a kindling stimulus in previously pentylenetetrazol-kindled rats (cross-kindling). Chronic exposure to dieldrin facilitates kindling produced by daily electrical stimulation of the amygdala. Even single, acute exposure, can facilitate kindling produced by electrical stimulation of the amygdala, 1 to 3 weeks later. We propose that the procedure of kindling is a useful one with which to assess neurotoxicity. Agents affecting kindling in laboratory animals are of particular concern to those individuals in a population with demonstrable seizure susceptibility, those predisposed to convulsive disorders and others vulnerable to increased levels of CNS excitability.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-124 |
| Number of pages | 8 |
| Journal | Neurobehavioral Toxicology and Teratology |
| Volume | 2 |
| Issue number | 2 |
| State | Published - 1980 |
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ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Toxicology
- Embryology
Cite this
The kindled seizure : Production of and modification by dieldrin in rats. / Joy, R. M.; Stark, L. G.; Peterson, S. L.; Bowyer, J. F.; Albertson, Timothy E.
In: Neurobehavioral Toxicology and Teratology, Vol. 2, No. 2, 1980, p. 117-124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The kindled seizure
T2 - Production of and modification by dieldrin in rats
AU - Joy, R. M.
AU - Stark, L. G.
AU - Peterson, S. L.
AU - Bowyer, J. F.
AU - Albertson, Timothy E
PY - 1980
Y1 - 1980
N2 - In the rat dieldrin can evoke a progressive increase in the severity of convulsive responses (kindling) during repetitive exposures that cannot be attributed to simple accumulation of dieldrin in the brain. It can also replace pentylenetetrazol as a kindling stimulus in previously pentylenetetrazol-kindled rats (cross-kindling). Chronic exposure to dieldrin facilitates kindling produced by daily electrical stimulation of the amygdala. Even single, acute exposure, can facilitate kindling produced by electrical stimulation of the amygdala, 1 to 3 weeks later. We propose that the procedure of kindling is a useful one with which to assess neurotoxicity. Agents affecting kindling in laboratory animals are of particular concern to those individuals in a population with demonstrable seizure susceptibility, those predisposed to convulsive disorders and others vulnerable to increased levels of CNS excitability.
AB - In the rat dieldrin can evoke a progressive increase in the severity of convulsive responses (kindling) during repetitive exposures that cannot be attributed to simple accumulation of dieldrin in the brain. It can also replace pentylenetetrazol as a kindling stimulus in previously pentylenetetrazol-kindled rats (cross-kindling). Chronic exposure to dieldrin facilitates kindling produced by daily electrical stimulation of the amygdala. Even single, acute exposure, can facilitate kindling produced by electrical stimulation of the amygdala, 1 to 3 weeks later. We propose that the procedure of kindling is a useful one with which to assess neurotoxicity. Agents affecting kindling in laboratory animals are of particular concern to those individuals in a population with demonstrable seizure susceptibility, those predisposed to convulsive disorders and others vulnerable to increased levels of CNS excitability.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019141425&partnerID=8YFLogxK
M3 - Article
C2 - 7290307
AN - SCOPUS:0019141425
VL - 2
SP - 117
EP - 124
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
SN - 0892-0362
IS - 2
ER -