The kindled seizure: Production of and modification by dieldrin in rats

R. M. Joy, L. G. Stark, S. L. Peterson, J. F. Bowyer, Timothy E Albertson

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In the rat dieldrin can evoke a progressive increase in the severity of convulsive responses (kindling) during repetitive exposures that cannot be attributed to simple accumulation of dieldrin in the brain. It can also replace pentylenetetrazol as a kindling stimulus in previously pentylenetetrazol-kindled rats (cross-kindling). Chronic exposure to dieldrin facilitates kindling produced by daily electrical stimulation of the amygdala. Even single, acute exposure, can facilitate kindling produced by electrical stimulation of the amygdala, 1 to 3 weeks later. We propose that the procedure of kindling is a useful one with which to assess neurotoxicity. Agents affecting kindling in laboratory animals are of particular concern to those individuals in a population with demonstrable seizure susceptibility, those predisposed to convulsive disorders and others vulnerable to increased levels of CNS excitability.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalNeurobehavioral Toxicology and Teratology
Volume2
Issue number2
StatePublished - 1980

Fingerprint

Dieldrin
Rats
Pentylenetetrazole
Seizures
Amygdala
Electric Stimulation
Laboratory Animals
Brain
Animals
Population

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Toxicology
  • Embryology

Cite this

The kindled seizure : Production of and modification by dieldrin in rats. / Joy, R. M.; Stark, L. G.; Peterson, S. L.; Bowyer, J. F.; Albertson, Timothy E.

In: Neurobehavioral Toxicology and Teratology, Vol. 2, No. 2, 1980, p. 117-124.

Research output: Contribution to journalArticle

Joy, R. M. ; Stark, L. G. ; Peterson, S. L. ; Bowyer, J. F. ; Albertson, Timothy E. / The kindled seizure : Production of and modification by dieldrin in rats. In: Neurobehavioral Toxicology and Teratology. 1980 ; Vol. 2, No. 2. pp. 117-124.
@article{6fd452c5f4264c5a968ccecda383c432,
title = "The kindled seizure: Production of and modification by dieldrin in rats",
abstract = "In the rat dieldrin can evoke a progressive increase in the severity of convulsive responses (kindling) during repetitive exposures that cannot be attributed to simple accumulation of dieldrin in the brain. It can also replace pentylenetetrazol as a kindling stimulus in previously pentylenetetrazol-kindled rats (cross-kindling). Chronic exposure to dieldrin facilitates kindling produced by daily electrical stimulation of the amygdala. Even single, acute exposure, can facilitate kindling produced by electrical stimulation of the amygdala, 1 to 3 weeks later. We propose that the procedure of kindling is a useful one with which to assess neurotoxicity. Agents affecting kindling in laboratory animals are of particular concern to those individuals in a population with demonstrable seizure susceptibility, those predisposed to convulsive disorders and others vulnerable to increased levels of CNS excitability.",
author = "Joy, {R. M.} and Stark, {L. G.} and Peterson, {S. L.} and Bowyer, {J. F.} and Albertson, {Timothy E}",
year = "1980",
language = "English (US)",
volume = "2",
pages = "117--124",
journal = "Neurotoxicology and Teratology",
issn = "0892-0362",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - The kindled seizure

T2 - Production of and modification by dieldrin in rats

AU - Joy, R. M.

AU - Stark, L. G.

AU - Peterson, S. L.

AU - Bowyer, J. F.

AU - Albertson, Timothy E

PY - 1980

Y1 - 1980

N2 - In the rat dieldrin can evoke a progressive increase in the severity of convulsive responses (kindling) during repetitive exposures that cannot be attributed to simple accumulation of dieldrin in the brain. It can also replace pentylenetetrazol as a kindling stimulus in previously pentylenetetrazol-kindled rats (cross-kindling). Chronic exposure to dieldrin facilitates kindling produced by daily electrical stimulation of the amygdala. Even single, acute exposure, can facilitate kindling produced by electrical stimulation of the amygdala, 1 to 3 weeks later. We propose that the procedure of kindling is a useful one with which to assess neurotoxicity. Agents affecting kindling in laboratory animals are of particular concern to those individuals in a population with demonstrable seizure susceptibility, those predisposed to convulsive disorders and others vulnerable to increased levels of CNS excitability.

AB - In the rat dieldrin can evoke a progressive increase in the severity of convulsive responses (kindling) during repetitive exposures that cannot be attributed to simple accumulation of dieldrin in the brain. It can also replace pentylenetetrazol as a kindling stimulus in previously pentylenetetrazol-kindled rats (cross-kindling). Chronic exposure to dieldrin facilitates kindling produced by daily electrical stimulation of the amygdala. Even single, acute exposure, can facilitate kindling produced by electrical stimulation of the amygdala, 1 to 3 weeks later. We propose that the procedure of kindling is a useful one with which to assess neurotoxicity. Agents affecting kindling in laboratory animals are of particular concern to those individuals in a population with demonstrable seizure susceptibility, those predisposed to convulsive disorders and others vulnerable to increased levels of CNS excitability.

UR - http://www.scopus.com/inward/record.url?scp=0019141425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019141425&partnerID=8YFLogxK

M3 - Article

C2 - 7290307

AN - SCOPUS:0019141425

VL - 2

SP - 117

EP - 124

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - 2

ER -