Abstract
We have shown that the larynx has a prominent immunological component that varies between individuals, and which is influenced by lifestyle factors implicated in the pathogenesis of the inflammatory and neoplastic diseases of the larynx. In order to explore the mechanisms of such links between laryngeal mucosal immunity and the development of lifestyle-related disease, reliable in vitro models are essential. In this study, we isolated and characterised primary laryngeal epithelial cells from normal individuals and show they can be cultured and manipulated to express MHC class II molecules in vitro.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 725-730 |
| Number of pages | 6 |
| Journal | Molecular Immunology |
| Volume | 43 |
| Issue number | 6 |
| DOIs | |
| State | Published - Feb 2006 |
| Externally published | Yes |
Keywords
- Epithelial cells
- MHC class II
- Serum-free medium
- Transplantation
ASJC Scopus subject areas
- Molecular Biology
- Immunology
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Cite this
Rees, L. E. N., Gunasekaran, S., Sipaul, F., Birchall, M. A., & Bailey, M. (2006). The isolation and characterisation of primary human laryngeal epithelial cells. Molecular Immunology, 43(6), 725-730. https://doi.org/10.1016/j.molimm.2005.03.017