Abstract
The etiology and pathogenesis of autoimmune diseases remains largely enigmatic despite numerous hints provided by basic science and clinical observations. We are convinced that similar factors and mechanisms may underlie different conditions, as well illustrated by the female predominance or the association with serum autoantibodies shared by different groups of patients. Genomic variability is largely insufficient to explain the individual susceptibility to systemic lupus erythematosus, rheumatoid arthritis, and systemic sclerosis. This is demonstrated by data from large genome-wide association studies and, more importantly, from concordance rates in monozygotic and dizygotic twins. Indeed, we are convinced that environmental factors are pivotal in determining the onset of autoimmunity and explaining the epidemiological variability in disease prevalence. Epigenetics (DNA methylation, histone changes, microRNA) represent the ideal link between environmental factors (gut microbiota, diet, infections and xenobiotics) and disease incidence and for this reason we propose that the parallel study of these areas should be coined geoepigenetics.
| Original language | English (US) |
|---|---|
| Title of host publication | Diet-Microbe Interactions in the Gut: Effects on Human Health and Disease |
| Publisher | Elsevier Inc. |
| Pages | 139-148 |
| Number of pages | 10 |
| ISBN (Print) | 9780124079410, 9780124078253 |
| DOIs | |
| State | Published - Aug 12 2014 |
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Keywords
- DNA methylation
- Geoepidemiology
- Hhistone code
- Infectious agents
- MicroRNA
- Monozygotic twins
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Systemic sclerosis
- Tolerance breakdown
- Xenobiotics
ASJC Scopus subject areas
- Medicine(all)
Cite this
The Interplay of Epigenetics and Epidemiology in Autoimmune Diseases : Time for Geoepigenetics. / Selmi, Carlo; Ceribelli, Angela.
Diet-Microbe Interactions in the Gut: Effects on Human Health and Disease. Elsevier Inc., 2014. p. 139-148.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - The Interplay of Epigenetics and Epidemiology in Autoimmune Diseases
T2 - Time for Geoepigenetics
AU - Selmi, Carlo
AU - Ceribelli, Angela
PY - 2014/8/12
Y1 - 2014/8/12
N2 - The etiology and pathogenesis of autoimmune diseases remains largely enigmatic despite numerous hints provided by basic science and clinical observations. We are convinced that similar factors and mechanisms may underlie different conditions, as well illustrated by the female predominance or the association with serum autoantibodies shared by different groups of patients. Genomic variability is largely insufficient to explain the individual susceptibility to systemic lupus erythematosus, rheumatoid arthritis, and systemic sclerosis. This is demonstrated by data from large genome-wide association studies and, more importantly, from concordance rates in monozygotic and dizygotic twins. Indeed, we are convinced that environmental factors are pivotal in determining the onset of autoimmunity and explaining the epidemiological variability in disease prevalence. Epigenetics (DNA methylation, histone changes, microRNA) represent the ideal link between environmental factors (gut microbiota, diet, infections and xenobiotics) and disease incidence and for this reason we propose that the parallel study of these areas should be coined geoepigenetics.
AB - The etiology and pathogenesis of autoimmune diseases remains largely enigmatic despite numerous hints provided by basic science and clinical observations. We are convinced that similar factors and mechanisms may underlie different conditions, as well illustrated by the female predominance or the association with serum autoantibodies shared by different groups of patients. Genomic variability is largely insufficient to explain the individual susceptibility to systemic lupus erythematosus, rheumatoid arthritis, and systemic sclerosis. This is demonstrated by data from large genome-wide association studies and, more importantly, from concordance rates in monozygotic and dizygotic twins. Indeed, we are convinced that environmental factors are pivotal in determining the onset of autoimmunity and explaining the epidemiological variability in disease prevalence. Epigenetics (DNA methylation, histone changes, microRNA) represent the ideal link between environmental factors (gut microbiota, diet, infections and xenobiotics) and disease incidence and for this reason we propose that the parallel study of these areas should be coined geoepigenetics.
KW - DNA methylation
KW - Geoepidemiology
KW - Hhistone code
KW - Infectious agents
KW - MicroRNA
KW - Monozygotic twins
KW - Rheumatoid arthritis
KW - Systemic lupus erythematosus
KW - Systemic sclerosis
KW - Tolerance breakdown
KW - Xenobiotics
UR - http://www.scopus.com/inward/record.url?scp=84942133981&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942133981&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-407825-3.00010-1
DO - 10.1016/B978-0-12-407825-3.00010-1
M3 - Chapter
AN - SCOPUS:84942133981
SN - 9780124079410
SN - 9780124078253
SP - 139
EP - 148
BT - Diet-Microbe Interactions in the Gut: Effects on Human Health and Disease
PB - Elsevier Inc.
ER -