The InterLACE study: Design, data harmonization and characteristics across 20 studies on women's health

Gita D. Mishra, Hsin Fang Chung, Nirmala Pandeya, Annette J. Dobson, Lee Jones, Nancy E. Avis, Sybil L. Crawford, Ellen B Gold, Daniel Brown, Lynette L. Sievert, Eric Brunner, Janet E. Cade, Victoria J. Burley, Darren C. Greenwood, Graham G. Giles, Fiona Bruinsma, Alissa Goodman, Kunihiko Hayashi, Jung Su Lee, Hideki MizunumaDiana Kuh, Rachel Cooper, Rebecca Hardy, Carla Makhlouf Obermeyer, Kathryn A. Lee, Mette Kildevæld Simonsen, Toyoko Yoshizawa, Nancy F. Woods, Ellen S. Mitchell, Mark Hamer, Panayotes Demakakos, Sven Sandin, Hans Olov Adami, Elisabete Weiderpass, Debra Anderson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women's reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE. Study design InterLACE is an individual-level pooled study of 20 observational studies (12 of which are longitudinal) from ten countries. Variables were harmonized across studies to create a new and systematic synthesis of life-course data. Main outcome measures Harmonized data were derived in three domains: 1) socio-demographic and lifestyle factors, 2) female reproductive characteristics, and 3) chronic disease outcomes (cardiovascular disease (CVD) and diabetes). Results InterLACE pooled data from 229,054 mid-aged women. Overall, 76% of the women were Caucasian and 22% Japanese; other ethnicities (of 300 or more participants) included Hispanic/Latin American (0.2%), Chinese (0.2%), Middle Eastern (0.3%), African/black (0.5%), and Other (1.0%). The median age at baseline was 47 years (Inter-quartile range (IQR): 41–53), and that at the last follow-up was 56 years (IQR: 48–64). Regarding reproductive characteristics, half of the women (49.8%) had their first menstruation (menarche) at 12–13 years of age. The distribution of menopausal status and the prevalence of chronic disease varied considerably among studies. At baseline, most women (57%) were pre- or peri-menopausal, 20% reported a natural menopause (range 0.8–55.6%) and the remainder had surgery or were taking hormones. By the end of follow-up, the prevalence rates of CVD and diabetes were 7.2% (range 0.9–24.6%) and 5.1% (range 1.3–13.2%), respectively. Conclusions The scale and heterogeneity of InterLACE data provide an opportunity to strengthen evidence concerning the relationships between reproductive health through life and subsequent risks of chronic disease, including cross-cultural comparisons.

Original languageEnglish (US)
Pages (from-to)176-185
Number of pages10
JournalMaturitas
Volume92
DOIs
StatePublished - Oct 1 2016

Fingerprint

Women's Health
Chronic Disease
Reproductive Health
Cardiovascular Diseases
Medical problems
Demography
Cross-Cultural Comparison
Menarche
Menstruation
Health
Menopause
Hispanic Americans
Observational Studies
Life Style
Cross-Sectional Studies
Outcome Assessment (Health Care)
Hormones
Surgery
Research

Keywords

  • Baseline characteristics
  • Chronic disease
  • Cross-cultural comparison
  • Harmonization
  • Life-course research
  • Reproductive health

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynecology

Cite this

Mishra, G. D., Chung, H. F., Pandeya, N., Dobson, A. J., Jones, L., Avis, N. E., ... Anderson, D. (2016). The InterLACE study: Design, data harmonization and characteristics across 20 studies on women's health. Maturitas, 92, 176-185. https://doi.org/10.1016/j.maturitas.2016.07.021

The InterLACE study : Design, data harmonization and characteristics across 20 studies on women's health. / Mishra, Gita D.; Chung, Hsin Fang; Pandeya, Nirmala; Dobson, Annette J.; Jones, Lee; Avis, Nancy E.; Crawford, Sybil L.; Gold, Ellen B; Brown, Daniel; Sievert, Lynette L.; Brunner, Eric; Cade, Janet E.; Burley, Victoria J.; Greenwood, Darren C.; Giles, Graham G.; Bruinsma, Fiona; Goodman, Alissa; Hayashi, Kunihiko; Lee, Jung Su; Mizunuma, Hideki; Kuh, Diana; Cooper, Rachel; Hardy, Rebecca; Obermeyer, Carla Makhlouf; Lee, Kathryn A.; Simonsen, Mette Kildevæld; Yoshizawa, Toyoko; Woods, Nancy F.; Mitchell, Ellen S.; Hamer, Mark; Demakakos, Panayotes; Sandin, Sven; Adami, Hans Olov; Weiderpass, Elisabete; Anderson, Debra.

In: Maturitas, Vol. 92, 01.10.2016, p. 176-185.

Research output: Contribution to journalArticle

Mishra, GD, Chung, HF, Pandeya, N, Dobson, AJ, Jones, L, Avis, NE, Crawford, SL, Gold, EB, Brown, D, Sievert, LL, Brunner, E, Cade, JE, Burley, VJ, Greenwood, DC, Giles, GG, Bruinsma, F, Goodman, A, Hayashi, K, Lee, JS, Mizunuma, H, Kuh, D, Cooper, R, Hardy, R, Obermeyer, CM, Lee, KA, Simonsen, MK, Yoshizawa, T, Woods, NF, Mitchell, ES, Hamer, M, Demakakos, P, Sandin, S, Adami, HO, Weiderpass, E & Anderson, D 2016, 'The InterLACE study: Design, data harmonization and characteristics across 20 studies on women's health', Maturitas, vol. 92, pp. 176-185. https://doi.org/10.1016/j.maturitas.2016.07.021
Mishra, Gita D. ; Chung, Hsin Fang ; Pandeya, Nirmala ; Dobson, Annette J. ; Jones, Lee ; Avis, Nancy E. ; Crawford, Sybil L. ; Gold, Ellen B ; Brown, Daniel ; Sievert, Lynette L. ; Brunner, Eric ; Cade, Janet E. ; Burley, Victoria J. ; Greenwood, Darren C. ; Giles, Graham G. ; Bruinsma, Fiona ; Goodman, Alissa ; Hayashi, Kunihiko ; Lee, Jung Su ; Mizunuma, Hideki ; Kuh, Diana ; Cooper, Rachel ; Hardy, Rebecca ; Obermeyer, Carla Makhlouf ; Lee, Kathryn A. ; Simonsen, Mette Kildevæld ; Yoshizawa, Toyoko ; Woods, Nancy F. ; Mitchell, Ellen S. ; Hamer, Mark ; Demakakos, Panayotes ; Sandin, Sven ; Adami, Hans Olov ; Weiderpass, Elisabete ; Anderson, Debra. / The InterLACE study : Design, data harmonization and characteristics across 20 studies on women's health. In: Maturitas. 2016 ; Vol. 92. pp. 176-185.
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abstract = "Objectives The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women's reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE. Study design InterLACE is an individual-level pooled study of 20 observational studies (12 of which are longitudinal) from ten countries. Variables were harmonized across studies to create a new and systematic synthesis of life-course data. Main outcome measures Harmonized data were derived in three domains: 1) socio-demographic and lifestyle factors, 2) female reproductive characteristics, and 3) chronic disease outcomes (cardiovascular disease (CVD) and diabetes). Results InterLACE pooled data from 229,054 mid-aged women. Overall, 76{\%} of the women were Caucasian and 22{\%} Japanese; other ethnicities (of 300 or more participants) included Hispanic/Latin American (0.2{\%}), Chinese (0.2{\%}), Middle Eastern (0.3{\%}), African/black (0.5{\%}), and Other (1.0{\%}). The median age at baseline was 47 years (Inter-quartile range (IQR): 41–53), and that at the last follow-up was 56 years (IQR: 48–64). Regarding reproductive characteristics, half of the women (49.8{\%}) had their first menstruation (menarche) at 12–13 years of age. The distribution of menopausal status and the prevalence of chronic disease varied considerably among studies. At baseline, most women (57{\%}) were pre- or peri-menopausal, 20{\%} reported a natural menopause (range 0.8–55.6{\%}) and the remainder had surgery or were taking hormones. By the end of follow-up, the prevalence rates of CVD and diabetes were 7.2{\%} (range 0.9–24.6{\%}) and 5.1{\%} (range 1.3–13.2{\%}), respectively. Conclusions The scale and heterogeneity of InterLACE data provide an opportunity to strengthen evidence concerning the relationships between reproductive health through life and subsequent risks of chronic disease, including cross-cultural comparisons.",
keywords = "Baseline characteristics, Chronic disease, Cross-cultural comparison, Harmonization, Life-course research, Reproductive health",
author = "Mishra, {Gita D.} and Chung, {Hsin Fang} and Nirmala Pandeya and Dobson, {Annette J.} and Lee Jones and Avis, {Nancy E.} and Crawford, {Sybil L.} and Gold, {Ellen B} and Daniel Brown and Sievert, {Lynette L.} and Eric Brunner and Cade, {Janet E.} and Burley, {Victoria J.} and Greenwood, {Darren C.} and Giles, {Graham G.} and Fiona Bruinsma and Alissa Goodman and Kunihiko Hayashi and Lee, {Jung Su} and Hideki Mizunuma and Diana Kuh and Rachel Cooper and Rebecca Hardy and Obermeyer, {Carla Makhlouf} and Lee, {Kathryn A.} and Simonsen, {Mette Kildev{\ae}ld} and Toyoko Yoshizawa and Woods, {Nancy F.} and Mitchell, {Ellen S.} and Mark Hamer and Panayotes Demakakos and Sven Sandin and Adami, {Hans Olov} and Elisabete Weiderpass and Debra Anderson",
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TY - JOUR

T1 - The InterLACE study

T2 - Design, data harmonization and characteristics across 20 studies on women's health

AU - Mishra, Gita D.

AU - Chung, Hsin Fang

AU - Pandeya, Nirmala

AU - Dobson, Annette J.

AU - Jones, Lee

AU - Avis, Nancy E.

AU - Crawford, Sybil L.

AU - Gold, Ellen B

AU - Brown, Daniel

AU - Sievert, Lynette L.

AU - Brunner, Eric

AU - Cade, Janet E.

AU - Burley, Victoria J.

AU - Greenwood, Darren C.

AU - Giles, Graham G.

AU - Bruinsma, Fiona

AU - Goodman, Alissa

AU - Hayashi, Kunihiko

AU - Lee, Jung Su

AU - Mizunuma, Hideki

AU - Kuh, Diana

AU - Cooper, Rachel

AU - Hardy, Rebecca

AU - Obermeyer, Carla Makhlouf

AU - Lee, Kathryn A.

AU - Simonsen, Mette Kildevæld

AU - Yoshizawa, Toyoko

AU - Woods, Nancy F.

AU - Mitchell, Ellen S.

AU - Hamer, Mark

AU - Demakakos, Panayotes

AU - Sandin, Sven

AU - Adami, Hans Olov

AU - Weiderpass, Elisabete

AU - Anderson, Debra

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Objectives The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women's reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE. Study design InterLACE is an individual-level pooled study of 20 observational studies (12 of which are longitudinal) from ten countries. Variables were harmonized across studies to create a new and systematic synthesis of life-course data. Main outcome measures Harmonized data were derived in three domains: 1) socio-demographic and lifestyle factors, 2) female reproductive characteristics, and 3) chronic disease outcomes (cardiovascular disease (CVD) and diabetes). Results InterLACE pooled data from 229,054 mid-aged women. Overall, 76% of the women were Caucasian and 22% Japanese; other ethnicities (of 300 or more participants) included Hispanic/Latin American (0.2%), Chinese (0.2%), Middle Eastern (0.3%), African/black (0.5%), and Other (1.0%). The median age at baseline was 47 years (Inter-quartile range (IQR): 41–53), and that at the last follow-up was 56 years (IQR: 48–64). Regarding reproductive characteristics, half of the women (49.8%) had their first menstruation (menarche) at 12–13 years of age. The distribution of menopausal status and the prevalence of chronic disease varied considerably among studies. At baseline, most women (57%) were pre- or peri-menopausal, 20% reported a natural menopause (range 0.8–55.6%) and the remainder had surgery or were taking hormones. By the end of follow-up, the prevalence rates of CVD and diabetes were 7.2% (range 0.9–24.6%) and 5.1% (range 1.3–13.2%), respectively. Conclusions The scale and heterogeneity of InterLACE data provide an opportunity to strengthen evidence concerning the relationships between reproductive health through life and subsequent risks of chronic disease, including cross-cultural comparisons.

AB - Objectives The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women's reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE. Study design InterLACE is an individual-level pooled study of 20 observational studies (12 of which are longitudinal) from ten countries. Variables were harmonized across studies to create a new and systematic synthesis of life-course data. Main outcome measures Harmonized data were derived in three domains: 1) socio-demographic and lifestyle factors, 2) female reproductive characteristics, and 3) chronic disease outcomes (cardiovascular disease (CVD) and diabetes). Results InterLACE pooled data from 229,054 mid-aged women. Overall, 76% of the women were Caucasian and 22% Japanese; other ethnicities (of 300 or more participants) included Hispanic/Latin American (0.2%), Chinese (0.2%), Middle Eastern (0.3%), African/black (0.5%), and Other (1.0%). The median age at baseline was 47 years (Inter-quartile range (IQR): 41–53), and that at the last follow-up was 56 years (IQR: 48–64). Regarding reproductive characteristics, half of the women (49.8%) had their first menstruation (menarche) at 12–13 years of age. The distribution of menopausal status and the prevalence of chronic disease varied considerably among studies. At baseline, most women (57%) were pre- or peri-menopausal, 20% reported a natural menopause (range 0.8–55.6%) and the remainder had surgery or were taking hormones. By the end of follow-up, the prevalence rates of CVD and diabetes were 7.2% (range 0.9–24.6%) and 5.1% (range 1.3–13.2%), respectively. Conclusions The scale and heterogeneity of InterLACE data provide an opportunity to strengthen evidence concerning the relationships between reproductive health through life and subsequent risks of chronic disease, including cross-cultural comparisons.

KW - Baseline characteristics

KW - Chronic disease

KW - Cross-cultural comparison

KW - Harmonization

KW - Life-course research

KW - Reproductive health

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