Abstract
Several studies have demonstrated the significance of a spatial cognitive map and its role for guided and accurate navigation through the environment. Learning and recalling spatial knowledge depends upon proper topological and metric spatial information processing. The present objectives are to better characterize the role of the hippocampus for processing topological and metric spatial information. Rats with dorsal hippocampal subregional lesions (dDG, dCA3, dCA1) were tested on a previously established metric task and topological task. The results of the present study suggest that dCA1, but not dDG or dCA3, mediates topological memory. Furthermore, dDG, dCA3, and dCA1 mediate metric memory. Dorsal DG is required for spatial information processing via pattern separation or orthogonalization of sensory inputs to generate metric representations. Dorsal CA3 and dCA1 then receive these metric representations transmitted from dDG along the trisynaptic loop. The present data add to a growing body of literature suggesting a diversity of function among the hippocampal subregions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 16-26 |
| Number of pages | 11 |
| Journal | Behavioral Neuroscience |
| Volume | 122 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2008 |
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Keywords
- dorsal CA1
- dorsal CA3
- dorsal DG
- metric
- topological
ASJC Scopus subject areas
- Behavioral Neuroscience
- Clinical Psychology
Cite this
The Interactions and Dissociations of the Dorsal Hippocampus Subregions : How the Dentate Gyrus, CA3, and CA1 Process Spatial Information. / Goodrich-Hunsaker, Naomi J.; Hunsaker, Michael R.; Kesner, Raymond P.
In: Behavioral Neuroscience, Vol. 122, No. 1, 02.2008, p. 16-26.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Interactions and Dissociations of the Dorsal Hippocampus Subregions
T2 - How the Dentate Gyrus, CA3, and CA1 Process Spatial Information
AU - Goodrich-Hunsaker, Naomi J.
AU - Hunsaker, Michael R.
AU - Kesner, Raymond P.
PY - 2008/2
Y1 - 2008/2
N2 - Several studies have demonstrated the significance of a spatial cognitive map and its role for guided and accurate navigation through the environment. Learning and recalling spatial knowledge depends upon proper topological and metric spatial information processing. The present objectives are to better characterize the role of the hippocampus for processing topological and metric spatial information. Rats with dorsal hippocampal subregional lesions (dDG, dCA3, dCA1) were tested on a previously established metric task and topological task. The results of the present study suggest that dCA1, but not dDG or dCA3, mediates topological memory. Furthermore, dDG, dCA3, and dCA1 mediate metric memory. Dorsal DG is required for spatial information processing via pattern separation or orthogonalization of sensory inputs to generate metric representations. Dorsal CA3 and dCA1 then receive these metric representations transmitted from dDG along the trisynaptic loop. The present data add to a growing body of literature suggesting a diversity of function among the hippocampal subregions.
AB - Several studies have demonstrated the significance of a spatial cognitive map and its role for guided and accurate navigation through the environment. Learning and recalling spatial knowledge depends upon proper topological and metric spatial information processing. The present objectives are to better characterize the role of the hippocampus for processing topological and metric spatial information. Rats with dorsal hippocampal subregional lesions (dDG, dCA3, dCA1) were tested on a previously established metric task and topological task. The results of the present study suggest that dCA1, but not dDG or dCA3, mediates topological memory. Furthermore, dDG, dCA3, and dCA1 mediate metric memory. Dorsal DG is required for spatial information processing via pattern separation or orthogonalization of sensory inputs to generate metric representations. Dorsal CA3 and dCA1 then receive these metric representations transmitted from dDG along the trisynaptic loop. The present data add to a growing body of literature suggesting a diversity of function among the hippocampal subregions.
KW - dorsal CA1
KW - dorsal CA3
KW - dorsal DG
KW - metric
KW - topological
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UR - http://www.scopus.com/inward/citedby.url?scp=40749130747&partnerID=8YFLogxK
U2 - 10.1037/0735-7044.122.1.16
DO - 10.1037/0735-7044.122.1.16
M3 - Article
VL - 122
SP - 16
EP - 26
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
SN - 0735-7044
IS - 1
ER -