The insulin signaling cascade from nematodes to mammals: Insights into innate immunity of Anopheles mosquitoes to malaria parasite infection

Shirley Luckhart, Michael A. Riehle

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

As revealed over the past 20 years, the insulin signaling cascade plays a central role in regulating immune and oxidative stress responses that affect the life spans of mammals and two model invertebrates, the nematode Caenorhabitis elegans and the fruit fly Drosophila melanogaster. In mosquitoes, insulin signaling regulates key steps in egg maturation and immunity and likely affects aging, although the latter has yet to be examined in detail. Reproduction, immunity and aging critically influence the capacity of mosquitoes to effectively transmit malaria parasites. Current work has demonstrated that molecules from the invading parasite and the blood meal elicit functional responses in female mosquitoes that are regulated through the insulin signaling pathway or by cross-talk with interacting pathways. Defining the details of these regulatory interactions presents significant challenges for future research, but will increase our understanding of mosquito/malaria parasite transmission and of the conservation of insulin signaling as a key regulatory nexus in animal biology.

Original languageEnglish (US)
Pages (from-to)647-656
Number of pages10
JournalDevelopmental and Comparative Immunology
Volume31
Issue number7
DOIs
StatePublished - 2007

Fingerprint

Parasitic Diseases
Anopheles
Culicidae
Innate Immunity
Malaria
Mammals
Insulin
Parasites
Immunity
Invertebrates
Drosophila melanogaster
Diptera
Reproduction
Ovum
Meals
Fruit
Oxidative Stress

Keywords

  • Aging
  • Anopheles
  • Innate immunity
  • Insulin
  • Malaria
  • Mosquito
  • Nitric oxide
  • Oxidative stress
  • Plasmodium
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Developmental Biology
  • Immunology

Cite this

The insulin signaling cascade from nematodes to mammals : Insights into innate immunity of Anopheles mosquitoes to malaria parasite infection. / Luckhart, Shirley; Riehle, Michael A.

In: Developmental and Comparative Immunology, Vol. 31, No. 7, 2007, p. 647-656.

Research output: Contribution to journalArticle

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