The insular claustrum in the methylazoxymethanol acetate (MAM) treated rats shows two different populations of neurons.

J. Moryś, Matthew Bobinski, B. Maciejewska, B. Berdel, P. B. Kozłowski, M. Dambska, H. M. Wisniewski, O. Narkiewicz

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Methylazoxymethanol acetate (MAM) is a substance that inhibits migration of neurons in the embryonic brain. After intraperitoneal injection of two different doses of MAM to pregnant rats, microcephaly with or without complete development of the cerebral cortex was observed in every litter. High MAM doses (30 mg/kg) resulted in the lack of superficial layers (II-IV) of the cerebral cortex when the deep layers (V, VI) were seen. The claustrum was present but composed of loosely packed, medium-size, triangular or fusiform neurons with anarchic oriented long axes. After administration of low MAM doses (14 mg/kg) two different parts (medial and lateral) of the insular claustrum were observed. Our results suggest that neurons of the insular claustrum create two different subpopulations of cells, which were similar to that observed in primitive insectivore (e.g., hedgehog), but fuse in development.

Original languageEnglish (US)
Title of host publicationFolia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences
Pages107-112
Number of pages6
Volume32
Edition2
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'The insular claustrum in the methylazoxymethanol acetate (MAM) treated rats shows two different populations of neurons.'. Together they form a unique fingerprint.

  • Cite this

    Moryś, J., Bobinski, M., Maciejewska, B., Berdel, B., Kozłowski, P. B., Dambska, M., Wisniewski, H. M., & Narkiewicz, O. (1994). The insular claustrum in the methylazoxymethanol acetate (MAM) treated rats shows two different populations of neurons. In Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences (2 ed., Vol. 32, pp. 107-112)