The 'ins' and 'outs' of intermediate filament organization

Pierre A. Coulombe, Olivier Bousquet, Linglei Ma, Soichiro Yamada, Denis Wirtz

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

A major function shared by several types of cytoplasmic intermediate filaments (IFs) is to stabilize cellular architecture against the mechanical forces it is subjected to. As for other fibrous cytoskeletal arrays, a crucial determinant of this function is the spatial organization of IFs in the cytoplasm. However, very few crossbridging proteins are specific for IFs - most IF-associated proteins known to exert a structural role act to tether IFs to other major cytoskeletal elements, such as F-actin, microtubules or adhesion complexes. In addition, IFs are endowed with the ability to participate in their own organization. This intriguing property is probably connected to the unusual degree of sequence diversity and sequence-specific regulation that characterize IF genes and their proteins. This dependence upon a combination of extrinsic and intrinsic determinants contributes to distinguish IFs from other fibrous cytoskeletal polymers and is key to their function. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)420-428
Number of pages9
JournalTrends in Cell Biology
Volume10
Issue number10
DOIs
StatePublished - Oct 1 2000
Externally publishedYes

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Intermediate Filaments
Intermediate Filament Proteins
Cytoskeleton
Microtubules
Actins
Polymers
Cytoplasm
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Coulombe, P. A., Bousquet, O., Ma, L., Yamada, S., & Wirtz, D. (2000). The 'ins' and 'outs' of intermediate filament organization. Trends in Cell Biology, 10(10), 420-428. https://doi.org/10.1016/S0962-8924(00)01828-6

The 'ins' and 'outs' of intermediate filament organization. / Coulombe, Pierre A.; Bousquet, Olivier; Ma, Linglei; Yamada, Soichiro; Wirtz, Denis.

In: Trends in Cell Biology, Vol. 10, No. 10, 01.10.2000, p. 420-428.

Research output: Contribution to journalArticle

Coulombe, PA, Bousquet, O, Ma, L, Yamada, S & Wirtz, D 2000, 'The 'ins' and 'outs' of intermediate filament organization', Trends in Cell Biology, vol. 10, no. 10, pp. 420-428. https://doi.org/10.1016/S0962-8924(00)01828-6
Coulombe, Pierre A. ; Bousquet, Olivier ; Ma, Linglei ; Yamada, Soichiro ; Wirtz, Denis. / The 'ins' and 'outs' of intermediate filament organization. In: Trends in Cell Biology. 2000 ; Vol. 10, No. 10. pp. 420-428.
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