Abstract
A major function shared by several types of cytoplasmic intermediate filaments (IFs) is to stabilize cellular architecture against the mechanical forces it is subjected to. As for other fibrous cytoskeletal arrays, a crucial determinant of this function is the spatial organization of IFs in the cytoplasm. However, very few crossbridging proteins are specific for IFs - most IF-associated proteins known to exert a structural role act to tether IFs to other major cytoskeletal elements, such as F-actin, microtubules or adhesion complexes. In addition, IFs are endowed with the ability to participate in their own organization. This intriguing property is probably connected to the unusual degree of sequence diversity and sequence-specific regulation that characterize IF genes and their proteins. This dependence upon a combination of extrinsic and intrinsic determinants contributes to distinguish IFs from other fibrous cytoskeletal polymers and is key to their function. Copyright (C) 2000 Elsevier Science Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 420-428 |
| Number of pages | 9 |
| Journal | Trends in Cell Biology |
| Volume | 10 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2000 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Cell Biology
Cite this
The 'ins' and 'outs' of intermediate filament organization. / Coulombe, Pierre A.; Bousquet, Olivier; Ma, Linglei; Yamada, Soichiro; Wirtz, Denis.
In: Trends in Cell Biology, Vol. 10, No. 10, 01.10.2000, p. 420-428.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The 'ins' and 'outs' of intermediate filament organization
AU - Coulombe, Pierre A.
AU - Bousquet, Olivier
AU - Ma, Linglei
AU - Yamada, Soichiro
AU - Wirtz, Denis
PY - 2000/10/1
Y1 - 2000/10/1
N2 - A major function shared by several types of cytoplasmic intermediate filaments (IFs) is to stabilize cellular architecture against the mechanical forces it is subjected to. As for other fibrous cytoskeletal arrays, a crucial determinant of this function is the spatial organization of IFs in the cytoplasm. However, very few crossbridging proteins are specific for IFs - most IF-associated proteins known to exert a structural role act to tether IFs to other major cytoskeletal elements, such as F-actin, microtubules or adhesion complexes. In addition, IFs are endowed with the ability to participate in their own organization. This intriguing property is probably connected to the unusual degree of sequence diversity and sequence-specific regulation that characterize IF genes and their proteins. This dependence upon a combination of extrinsic and intrinsic determinants contributes to distinguish IFs from other fibrous cytoskeletal polymers and is key to their function. Copyright (C) 2000 Elsevier Science Ltd.
AB - A major function shared by several types of cytoplasmic intermediate filaments (IFs) is to stabilize cellular architecture against the mechanical forces it is subjected to. As for other fibrous cytoskeletal arrays, a crucial determinant of this function is the spatial organization of IFs in the cytoplasm. However, very few crossbridging proteins are specific for IFs - most IF-associated proteins known to exert a structural role act to tether IFs to other major cytoskeletal elements, such as F-actin, microtubules or adhesion complexes. In addition, IFs are endowed with the ability to participate in their own organization. This intriguing property is probably connected to the unusual degree of sequence diversity and sequence-specific regulation that characterize IF genes and their proteins. This dependence upon a combination of extrinsic and intrinsic determinants contributes to distinguish IFs from other fibrous cytoskeletal polymers and is key to their function. Copyright (C) 2000 Elsevier Science Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0034308278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034308278&partnerID=8YFLogxK
U2 - 10.1016/S0962-8924(00)01828-6
DO - 10.1016/S0962-8924(00)01828-6
M3 - Article
C2 - 10998598
AN - SCOPUS:0034308278
VL - 10
SP - 420
EP - 428
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 10
ER -