The influence of portoenterostomy on transplantation for biliary atresia

Brendan C. Visser, Insoo Suh, Shinjiro Hirose, Philip Rosethal, Hanmin Lee, John P. Roberts, Ryutaro Hirose

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

After portoenterostomy (PE) for biliary atresia (BA), many patients suffer progressive deterioration of liver function and ultimately require liver transplantation. We retrospectively reviewed a single center's experience with pediatric liver transplantation for BA from 1988 to 2002. Sixty-six patients underwent 69 liver transplants for BA. Forty-two (63%) patients had previously undergone Kasai PE, 11 (17%) biliary appendicoduodenostomy (BAD), and 13 (20%) had no prior biliary drainage (NBD). The BAD procedure offered only short-term biliary drainage - the mean interval between PE and transplant was more than twice that for Kasai patients than for BAD patients (132 versus 49 weeks). The transplants included 11 cadaveric partial, 27 cadaveric whole, and 31 living related transplants. Three patients required retransplant. Prior PE did not increase the incidence of major perioperative complications or unplanned reexploration. After transplant, the 1-, 5-, and 10-year actuarial graft survival rates were 87%, 86%, and 80%, respectively. The 1-, 5-, and 10-year actuarial patient survival rates were 91%, 89%, and 83%. PE remains an important bridge to transplant. In conclusion, transplantation for BA offers excellent long-term graft and patient survival.

Original languageEnglish (US)
Pages (from-to)1279-1286
Number of pages8
JournalLiver Transplantation
Volume10
Issue number10
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

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Biliary Atresia
Transplantation
Transplants
Graft Survival
Liver Transplantation
Drainage
Survival Rate
Liver
Pediatrics
Incidence

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Visser, B. C., Suh, I., Hirose, S., Rosethal, P., Lee, H., Roberts, J. P., & Hirose, R. (2004). The influence of portoenterostomy on transplantation for biliary atresia. Liver Transplantation, 10(10), 1279-1286. https://doi.org/10.1002/lt.20234

The influence of portoenterostomy on transplantation for biliary atresia. / Visser, Brendan C.; Suh, Insoo; Hirose, Shinjiro; Rosethal, Philip; Lee, Hanmin; Roberts, John P.; Hirose, Ryutaro.

In: Liver Transplantation, Vol. 10, No. 10, 01.10.2004, p. 1279-1286.

Research output: Contribution to journalArticle

Visser, BC, Suh, I, Hirose, S, Rosethal, P, Lee, H, Roberts, JP & Hirose, R 2004, 'The influence of portoenterostomy on transplantation for biliary atresia', Liver Transplantation, vol. 10, no. 10, pp. 1279-1286. https://doi.org/10.1002/lt.20234
Visser, Brendan C. ; Suh, Insoo ; Hirose, Shinjiro ; Rosethal, Philip ; Lee, Hanmin ; Roberts, John P. ; Hirose, Ryutaro. / The influence of portoenterostomy on transplantation for biliary atresia. In: Liver Transplantation. 2004 ; Vol. 10, No. 10. pp. 1279-1286.
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