The influence of milk oligosaccharides on microbiota of infants: opportunities for formulas.

Maciej Chichlowski, J. Bruce German, Carlito B Lebrilla, David A. Mills

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

In addition to a nutritive role, human milk also guides the development of a protective intestinal microbiota in the infant. Human milk possesses an overabundance of complex oligosaccharides that are indigestible by the infant yet are consumed by microbial populations in the developing intestine. These oligosaccharides are believed to facilitate enrichment of a healthy infant gastrointestinal microbiota, often associated with bifidobacteria. Advances in glycomics have enabled precise determination of milk glycan structures as well as identification of the specific glycans consumed by various gut microbes. Furthermore, genomic analysis of bifidobacteria from infants has revealed specific genetic loci related to milk oligosaccharide import and processing, suggesting coevolution between the human host, milk glycans, and the microbes they enrich. This review discusses the current understanding of how human milk oligosaccharides interact with the infant microbiota and examines the opportunities for translating this knowledge to improve the functionality of infant formulas.

Original languageEnglish (US)
Pages (from-to)331-351
Number of pages21
JournalAnnual review of food science and technology
Volume2
StatePublished - 2011
Externally publishedYes

Fingerprint

Infant Formula
Microbiota
Oligosaccharides
oligosaccharides
Human Milk
Milk
breast milk
milk
polysaccharides
Bifidobacterium
Polysaccharides
microorganisms
Glycomics
infant formulas
infants
coevolution
intestinal microorganisms
Genetic Loci
imports
intestines

ASJC Scopus subject areas

  • Food Science

Cite this

The influence of milk oligosaccharides on microbiota of infants : opportunities for formulas. / Chichlowski, Maciej; German, J. Bruce; Lebrilla, Carlito B; Mills, David A.

In: Annual review of food science and technology, Vol. 2, 2011, p. 331-351.

Research output: Contribution to journalArticle

Chichlowski, Maciej ; German, J. Bruce ; Lebrilla, Carlito B ; Mills, David A. / The influence of milk oligosaccharides on microbiota of infants : opportunities for formulas. In: Annual review of food science and technology. 2011 ; Vol. 2. pp. 331-351.
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