TY - JOUR
T1 - The influence of free DTPA on the dose distribution of yttrium-90 radiolabelled antibodies
AU - Farnsworth, Andrew P H
AU - Vaughan, Andrew T M
PY - 1989
Y1 - 1989
N2 - Yttrium-90 (90Y) bound to antibody via a DTPA group, was stable in-vitro until exposed to buffers below pH 5.4. It also exhibited minimal transchelation to transferrin during serum incubation. In-vivo, two 90Y labelled antibodies of the same isotype but different specificities, showed similar distributions in tumour-bearing animals. Subsequent administration of a DTPA solution removed activity from liver and bone. This suggests that these tissues contain an environment in which a proportion of yttrium is released from the antibody, in a form suitable for removal with DTPA.
AB - Yttrium-90 (90Y) bound to antibody via a DTPA group, was stable in-vitro until exposed to buffers below pH 5.4. It also exhibited minimal transchelation to transferrin during serum incubation. In-vivo, two 90Y labelled antibodies of the same isotype but different specificities, showed similar distributions in tumour-bearing animals. Subsequent administration of a DTPA solution removed activity from liver and bone. This suggests that these tissues contain an environment in which a proportion of yttrium is released from the antibody, in a form suitable for removal with DTPA.
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U2 - 10.1016/0883-2897(89)90063-9
DO - 10.1016/0883-2897(89)90063-9
M3 - Article
AN - SCOPUS:38249026486
VL - 16
SP - 499
EP - 504
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
SN - 0969-8051
IS - 5
ER -