The influence of free DTPA on the dose distribution of yttrium-90 radiolabelled antibodies

Andrew P H Farnsworth, Andrew T M Vaughan

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Yttrium-90 (90Y) bound to antibody via a DTPA group, was stable in-vitro until exposed to buffers below pH 5.4. It also exhibited minimal transchelation to transferrin during serum incubation. In-vivo, two 90Y labelled antibodies of the same isotype but different specificities, showed similar distributions in tumour-bearing animals. Subsequent administration of a DTPA solution removed activity from liver and bone. This suggests that these tissues contain an environment in which a proportion of yttrium is released from the antibody, in a form suitable for removal with DTPA.

Original languageEnglish (US)
Pages (from-to)499-504
Number of pages6
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume16
Issue number5
DOIs
StatePublished - 1989
Externally publishedYes

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