The influence of free DTPA on the dose distribution of yttrium-90 radiolabelled antibodies

A. P. Farnsworth h., Andrew T M Vaughan

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Yttrium-90 (90Y) bound to antibody via a DTPA group, was stable in-vitro until exposed to buffers below pH 5.4. It also exhibited minimal transchelation to transferring during serum incubation. In-vivo, two 90Y labelled antibodies of the same isotype but different specificities, showed similar distributions in tumour-bearing animals. Subsequent administration of a DTPA solution removed activity from liver and bone. This suggests that these tissues contain an environment in which a proportion of yttrium is released from the antibody, in a form suitable for removal with DTPA.

Original languageEnglish (US)
Pages (from-to)499-504
Number of pages6
JournalNuclear Medicine and Biology
Volume16
Issue number5
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'The influence of free DTPA on the dose distribution of yttrium-90 radiolabelled antibodies'. Together they form a unique fingerprint.

  • Cite this