The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice

José A. López-Domínguez, Jon J Ramsey, Dianna Tran, Denise Imai, Amanda Koehne, Steven T. Laing, Stephen M Griffey, Kyoungmi Kim, Sandra L. Taylor, Kevork Hagopian, José M. Villalba, Guillermo López-Lluch, Plácido Navas, Roger B. McDonald

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Calorie restriction (CR) without malnutrition extends life span in several animal models. It has been proposed that a decrease in the amount of polyunsaturated fatty acids (PUFAs), and especially n-3 fatty acids, in membrane phospholipids may contribute to life span extension with CR. Phospholipid PUFAs are sensitive to dietary fatty acid composition, and thus, the purpose of this study was to determine the influence of dietary lipids on life span in CR mice. C57BL/6J mice were assigned to four groups (a 5% CR control group and three 40% CR groups) and fed diets with soybean oil (high in n-6 PUFAs), fish oil (high in n-3 PUFAs), or lard (high in saturated and monounsaturated fatty acids) as the primary lipid source. Life span was increased (p

Original languageEnglish (US)
Pages (from-to)1181-1188
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number10
StatePublished - Nov 19 2014


  • Aging
  • Calorie restriction
  • Dietary fat
  • Fatty acids
  • Life span

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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