The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice

José A. López-Domínguez, Jon J Ramsey, Dianna Tran, Denise Imai, Amanda Koehne, Steven T. Laing, Stephen M Griffey, Kyoungmi Kim, Sandra L. Taylor, Kevork Hagopian, José M. Villalba, Guillermo López-Lluch, Plácido Navas, Roger B. McDonald

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Calorie restriction (CR) without malnutrition extends life span in several animal models. It has been proposed that a decrease in the amount of polyunsaturated fatty acids (PUFAs), and especially n-3 fatty acids, in membrane phospholipids may contribute to life span extension with CR. Phospholipid PUFAs are sensitive to dietary fatty acid composition, and thus, the purpose of this study was to determine the influence of dietary lipids on life span in CR mice. C57BL/6J mice were assigned to four groups (a 5% CR control group and three 40% CR groups) and fed diets with soybean oil (high in n-6 PUFAs), fish oil (high in n-3 PUFAs), or lard (high in saturated and monounsaturated fatty acids) as the primary lipid source. Life span was increased (p

Original languageEnglish (US)
Pages (from-to)1181-1188
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume70
Issue number10
DOIs
StatePublished - Nov 19 2014

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Dietary Fats
Unsaturated Fatty Acids
Omega-3 Fatty Acids
Phospholipids
Fatty Acids
Lipids
Monounsaturated Fatty Acids
Soybean Oil
Fish Oils
Life Expectancy
Inbred C57BL Mouse
Malnutrition
Animal Models
Diet
Control Groups
Membranes

Keywords

  • Aging
  • Calorie restriction
  • Dietary fat
  • Fatty acids
  • Life span

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice. / López-Domínguez, José A.; Ramsey, Jon J; Tran, Dianna; Imai, Denise; Koehne, Amanda; Laing, Steven T.; Griffey, Stephen M; Kim, Kyoungmi; Taylor, Sandra L.; Hagopian, Kevork; Villalba, José M.; López-Lluch, Guillermo; Navas, Plácido; McDonald, Roger B.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 70, No. 10, 19.11.2014, p. 1181-1188.

Research output: Contribution to journalArticle

López-Domínguez, JA, Ramsey, JJ, Tran, D, Imai, D, Koehne, A, Laing, ST, Griffey, SM, Kim, K, Taylor, SL, Hagopian, K, Villalba, JM, López-Lluch, G, Navas, P & McDonald, RB 2014, 'The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 70, no. 10, pp. 1181-1188. https://doi.org/10.1093/gerona/glu177
López-Domínguez, José A. ; Ramsey, Jon J ; Tran, Dianna ; Imai, Denise ; Koehne, Amanda ; Laing, Steven T. ; Griffey, Stephen M ; Kim, Kyoungmi ; Taylor, Sandra L. ; Hagopian, Kevork ; Villalba, José M. ; López-Lluch, Guillermo ; Navas, Plácido ; McDonald, Roger B. / The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2014 ; Vol. 70, No. 10. pp. 1181-1188.
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