The influence of cytoreductive surgery on the response to chemotherapy of a rat renal cancer

Ralph W deVere White, A. D. Deitch, W. K. Hong, C. A. Olsson

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The potential ability of cytoreductive surgery to increase the effectiveness of chemotherapy (vindesine) was tested utilizing male Wistar Lewis rats transplanted simulataneously with intraperitoneal and flank implants of a spontaneously arising renal adenocarcinoma. Cytoreduction was accomplished in some animals by removing the flank tumor 5-7 weeks following implantation; all animals received vindesine (IP injection of 0.5 mg/kg on two successive weeks). While vindesine reduced tumor growth, in no case did the addition of cytoreductive surgery enhance the effect of chemotherapy. The addition of cytoreductive surgery to marginally effective chemotherapy was found to be ineffective or even detrimental.

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalUrological Research
Volume13
Issue number1
DOIs
StatePublished - Jan 1985
Externally publishedYes

Keywords

  • Chemotherapy
  • Cytoreductive surgery
  • Rats
  • Renal adenocarcinoma

ASJC Scopus subject areas

  • Urology

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