The influence of codon context on genetic code translation

Lionello Bossi, John R. Roth

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

A class of mutations that increase the efficiency of a suppressor tRNA in translating a particular amber codon has been characterized. The increased efficiency is due to a mutation resulting in a change in the mRNA that affects the nucleotide adjacent to the 3′ side of the UAG triplet. Thus the interaction of tRNA with mRNA is influenced by mRNA sequences outside the triplet codon.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
JournalNature
Volume286
Issue number5769
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Genetic Code
Protein Biosynthesis
Codon
Transfer RNA
Messenger RNA
Mutation
Terminator Codon
Nucleotides

ASJC Scopus subject areas

  • General

Cite this

The influence of codon context on genetic code translation. / Bossi, Lionello; Roth, John R.

In: Nature, Vol. 286, No. 5769, 1980, p. 123-127.

Research output: Contribution to journalArticle

Bossi, L & Roth, JR 1980, 'The influence of codon context on genetic code translation', Nature, vol. 286, no. 5769, pp. 123-127. https://doi.org/10.1038/286123a0
Bossi, Lionello ; Roth, John R. / The influence of codon context on genetic code translation. In: Nature. 1980 ; Vol. 286, No. 5769. pp. 123-127.
@article{9e0353c4af7142a99ac3369daf0fe571,
title = "The influence of codon context on genetic code translation",
abstract = "A class of mutations that increase the efficiency of a suppressor tRNA in translating a particular amber codon has been characterized. The increased efficiency is due to a mutation resulting in a change in the mRNA that affects the nucleotide adjacent to the 3′ side of the UAG triplet. Thus the interaction of tRNA with mRNA is influenced by mRNA sequences outside the triplet codon.",
author = "Lionello Bossi and Roth, {John R.}",
year = "1980",
doi = "10.1038/286123a0",
language = "English (US)",
volume = "286",
pages = "123--127",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "5769",

}

TY - JOUR

T1 - The influence of codon context on genetic code translation

AU - Bossi, Lionello

AU - Roth, John R.

PY - 1980

Y1 - 1980

N2 - A class of mutations that increase the efficiency of a suppressor tRNA in translating a particular amber codon has been characterized. The increased efficiency is due to a mutation resulting in a change in the mRNA that affects the nucleotide adjacent to the 3′ side of the UAG triplet. Thus the interaction of tRNA with mRNA is influenced by mRNA sequences outside the triplet codon.

AB - A class of mutations that increase the efficiency of a suppressor tRNA in translating a particular amber codon has been characterized. The increased efficiency is due to a mutation resulting in a change in the mRNA that affects the nucleotide adjacent to the 3′ side of the UAG triplet. Thus the interaction of tRNA with mRNA is influenced by mRNA sequences outside the triplet codon.

UR - http://www.scopus.com/inward/record.url?scp=0019308408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019308408&partnerID=8YFLogxK

U2 - 10.1038/286123a0

DO - 10.1038/286123a0

M3 - Article

VL - 286

SP - 123

EP - 127

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5769

ER -