The influence of codon context on genetic code translation

Lionello Bossi, John R. Roth

Research output: Contribution to journalArticle

189 Scopus citations

Abstract

A class of mutations that increase the efficiency of a suppressor tRNA in translating a particular amber codon has been characterized. The increased efficiency is due to a mutation resulting in a change in the mRNA that affects the nucleotide adjacent to the 3′ side of the UAG triplet. Thus the interaction of tRNA with mRNA is influenced by mRNA sequences outside the triplet codon.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
JournalNature
Volume286
Issue number5769
DOIs
StatePublished - 1980
Externally publishedYes

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