Female, adult Swiss-Webster mice were fed, during gestation and subsequent lactation, diets containing either 25 (control), 500 or 1,000 μg Al/g diet in the form of Al lactate, followed by challenge with Listeria monocytogenes. Mice in the groups fed 1,000 and 500 μg Al/g had significantly lowered resistance to bacterial infection when compared to control animals (p < 0.025). The animals given 1,000 μg Al/g also had higher concentrations of liver Al (p < 0.05) than controls. Pups derived from these dams showed no differences in mortality rates or Al tissue levels. In contrast, nonpregnant animals fed 1,000 μg Al/g for 6 weeks had a slight decrease in mortality rate when compared to control animals. Dose-related changes in tissue Al levels were not observed in these adult, virgin mice. Finally, adult nonpregnant mice were injected subcutaneously with PBS only, or with 1, 5 or 10 mg of Al (in the form of Al lactate) per kilogram body weight followed by bacterial challenge. Animals which received 5 mg Al/kg had lower mortality rates to L. monocytogenes when compared to other treatment groups (p < 0.025). This data suggests that Al has the potential to influence host resistance to bacterial infection depending on the physiological state of the host; it provides additional evidence for the role of Al as an environmental toxin.
|Original language||English (US)|
|Number of pages||6|
|Journal||International Archives of Allergy and Applied Immunology|
|State||Published - 1989|
ASJC Scopus subject areas
- Immunology and Allergy