The induction of neutralizing antibodies by synthetic peptides of the envelope protein of type D simian retrovirus-1 (SRV-1)

Jose V Torres, Linda L. Werner, Arthur Malley, Eli Benjamini

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

It has been recently demonstrated that two serotypes of type D simian retroviruses, namely SRV-1 and SRV-2, exhibit extensive immunological cross-reactivity but do not exhibit cross-reactivity at the level of neutralizing antibodies. We have also shown recently that an area which includes residues 147-162 of the envelope protein of SRV-1 constitutes an epitope to which neutralizing antibodies against SRV-1 but not against SRV-2 are directed. However, in spite of the capacity of various immunogenic preparations to induce antibodies which react with SRV-1 these antibodies were incapable of neutralizing in vitro viral infectivity. Work reported herein demonstrates that various immunogens consisting of a larger peptide, namely 142-167 of the envelope protein of SRV-1, induce antibodies capable of binding with the envelope protein of SRV-1 and with the whole virus. Moreover, these antibodies exhibit the capacity to neutralize in vitro the infectivity of SRV-1 but not of SRV-2.

Original languageEnglish (US)
Pages (from-to)907-913
Number of pages7
JournalMolecular Immunology
Volume28
Issue number8
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Fingerprint Dive into the research topics of 'The induction of neutralizing antibodies by synthetic peptides of the envelope protein of type D simian retrovirus-1 (SRV-1)'. Together they form a unique fingerprint.

Cite this