The indispensable roles of microglia and astrocytes during brain development

Kitty Reemst, Stephen C Noctor, Paul J. Lucassen, Elly M. Hol

Research output: Contribution to journalArticlepeer-review

237 Scopus citations


Glia are essential for brain functioning during development and in the adult brain. Here, we discuss the various roles of both microglia and astrocytes, and their interactions during brain development. Although both cells are fundamentally different in origin and function, they often affect the same developmental processes such as neuro-/gliogenesis, angiogenesis, axonal outgrowth, synaptogenesis and synaptic pruning. Due to their important instructive roles in these processes, dysfunction of microglia or astrocytes during brain development could contribute to neurodevelopmental disorders and potentially even late-onset neuropathology. A better understanding of the origin, differentiation process and developmental functions of microglia and astrocytes will help to fully appreciate their role both in the developing as well as in the adult brain, in health and disease.

Original languageEnglish (US)
Article number566
JournalFrontiers in Human Neuroscience
Issue numberNOV2016
StatePublished - Nov 8 2016


  • Astrocytes
  • Brain development
  • Glial cells
  • Microglia
  • Neurodevelopmental disorders

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience


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