The in vivo effects of naproxen on canine experimental osteoarthritic articular cartilage: Composition, metalloproteinase activities and metabolism

A. Ratcliffe, M. P. Rosenwasser, F. Mahmud, P. A. Glazer, F. Saed-Nejad, Nancy E Lane, V. C. Mow

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A canine experimental model of osteoarthritis (OA), generated by arthroscopic transection of the anterior cruciate ligament (ACL) of the knee, was used to investigate the in vivo effects of the NSAID naproxen on the course of cartilage degeneration. The drug was given at the time of surgery, or from before surgery, and for 16 weeks after surgery. Analysis of the articular cartilage showed the naproxen was able to significantly suppress the decrease in proteoglycan content and metalloproteinase activities. The results indicate that pharmaceutical agents have the potential to modulate the progression of degenerative joint disease.

Original languageEnglish (US)
Pages (from-to)207-211
Number of pages5
JournalAgents and Actions
Volume39
Issue numberSUPPL.
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology

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    Ratcliffe, A., Rosenwasser, M. P., Mahmud, F., Glazer, P. A., Saed-Nejad, F., Lane, N. E., & Mow, V. C. (1993). The in vivo effects of naproxen on canine experimental osteoarthritic articular cartilage: Composition, metalloproteinase activities and metabolism. Agents and Actions, 39(SUPPL.), 207-211.