The importance of thrombotic risk factors in the development of idiopathic sudden hearing loss

Zuleyha Yildiz, Arzu Ulu, Armagan Incesulu, Yalcin Ozkaptan, Nejat Akar

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Impaired cochlear blood circulation has been suggested to cause sudden hearing loss. In this study, the role of factor V 1691 G-A (FV 1691 G-A), prothrombin 20210 G-A (PT 20210 G-A), methylene tetrahydrofolate reductase 677 C-T (MTHFR 677 C-T), factor V 4070 A-G (FV 4070 A-G), endothelial cell protein C receptor (EPCR) gene 23-bp insertion, and plasminogen activator inhibitor-1 (PAI-1) 4G/5G mutation was assessed. Fifty-three patients with idiopathic sudden sensorineural hearing loss and 80 individuals comprising the control group were included in this study. The frequency for FV 1691 A was 6.2% in the patient group and 3.7% in the control group, PT 20210 G-A was 1.2% in the patient group and 1.9% in the control group, and FV 4070 A-G was 7.5% in the patient group and 11.3% in the control group. The frequency of MTHFR 677 C-T was significantly higher in the patient group than in the control group, with a P value of.03. PAI-1-675 4G/5G polymorphism was found to be 71.2% and 69.8%, in the control group and the patient group, respectively. The EPCR 23-bp insertion was 0% in the control group and was found in 3 patients (3.7%), which needs further study.

Original languageEnglish (US)
Pages (from-to)356-359
Number of pages4
JournalClinical and Applied Thrombosis/Hemostasis
Volume14
Issue number3
DOIs
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

Sudden Hearing Loss
Control Groups
Factor V
Plasminogen Activator Inhibitor 1
Methylenetetrahydrofolate Reductase (NADPH2)
Gastrin-Secreting Cells
Sensorineural Hearing Loss
Blood Circulation
Cochlea
Prothrombin
Mutation

Keywords

  • EPCR
  • Idiopathic sudden hearing loss
  • Thrombotic risk factors
  • Vascular impairment

ASJC Scopus subject areas

  • Hematology

Cite this

The importance of thrombotic risk factors in the development of idiopathic sudden hearing loss. / Yildiz, Zuleyha; Ulu, Arzu; Incesulu, Armagan; Ozkaptan, Yalcin; Akar, Nejat.

In: Clinical and Applied Thrombosis/Hemostasis, Vol. 14, No. 3, 07.2008, p. 356-359.

Research output: Contribution to journalArticle

Yildiz, Zuleyha ; Ulu, Arzu ; Incesulu, Armagan ; Ozkaptan, Yalcin ; Akar, Nejat. / The importance of thrombotic risk factors in the development of idiopathic sudden hearing loss. In: Clinical and Applied Thrombosis/Hemostasis. 2008 ; Vol. 14, No. 3. pp. 356-359.
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