The implication of vitamin D and autoimmunity: A comprehensive review

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Abstract

Historically, vitamin D has been associated with the regulation of bone metabolism. However, increasing evidence demonstrates a strong association between vitamin D signaling and many biological processes that regulate immune responses. The discovery of the vitamin D receptor in multiple immune cell lineages, such as monocytes, dendritic cells, and activated T cells credits vitamin D with a novel role in modulating immunological functions and its subsequent role in the development or prevention of autoimmune diseases. In this review we, discuss five major areas in vitamin D biology of high immunological significance: (1) the metabolism of vitamin D; (2) the significance of vitamin D receptor polymorphisms in autoimmune diseases, such as multiple sclerosis, type 1 diabetes mellitus, and systemic lupus erythematosus; (3) vitamin D receptor transcriptional regulation of immune cell lineages, including Th1, Th17, Th2, regulatory T, and natural killer T cells; (4) the prevalence of vitamin D insufficiency/deficiency in patients with multiple sclerosis, type 1 diabetes mellitus, and systemic lupus erythematosus; and finally, (5) the therapeutic effects of vitamin D supplementation on disease severity and progression.

Original languageEnglish (US)
Pages (from-to)217-226
Number of pages10
JournalClinical Reviews in Allergy and Immunology
Volume45
Issue number2
DOIs
StatePublished - Oct 2013

Fingerprint

Autoimmunity
Vitamin D
Calcitriol Receptors
Cell Lineage
Type 1 Diabetes Mellitus
Systemic Lupus Erythematosus
Autoimmune Diseases
Multiple Sclerosis
Ergocalciferols
Biological Phenomena
Natural Killer T-Cells
Vitamin D Deficiency
Therapeutic Uses
Dendritic Cells
Disease Progression
Monocytes
T-Lymphocytes
Bone and Bones

Keywords

  • Autoimmunity
  • Multiple sclerosis
  • Systemic lupus erythematosus
  • Type 1 diabetes mellitus
  • Vitamin D

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

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